Fatal eosinophilic disease following autologous bone marrow transplantation

T. G. Gross, F. J. Hoge, J. D. Jackson, Paul Henry Sammut, Phyllis Irene Warkentin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A 15-year-old girl developed massive, fatal eosinophilic disease following autologous bone marrow transplantation (BMT) for Hodgkin's disease (HD). Prior to autologous BMT, the erythrocyte sedimentation rate (ESR) was elevated, with active HD, but eosinophilia was absent. Post-autologous BMT, ESR and peripheral eosinophilia were observed to correlate with respiratory symptoms. Initial evaluation revealed no recurrent tumor, infection or other identifiable etiology. A diagnosis of chronic eosinophilic pneumonia was made following lung biopsy. A complete response was initially achieved with steroid therapy; however, when steroid therapy was tapered, the eosinophilia and elevated ESR recurred with worsening respiratory symptoms. Terminally, severe pulmonary disease developed and recurrent HD was found in lung, lymph nodes and bone marrow. During episodes of eosinophilia, the patient's serum stimulated her bone marrow as well as control marrow to produce predominantly eosinophilic colonies. Eosinophilic colony production was not observed with patient's sera obtained prior to or during autologous BMT or with control sera. This patient died of eosinophilic inflammatory disease following autologous BMT. The etiology of this disease was not definitely identified but appeared to be due to an eosinophilic-stimulating factor which developed after autologous BMT.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalBone marrow transplantation
Volume14
Issue number2
StatePublished - Jan 1 1994

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Autologous Transplantation
Bone Marrow Transplantation
Eosinophilia
Blood Sedimentation
Hodgkin Disease
Bone Marrow
Serum
Steroids
Lung
Lung Diseases
Lymph Nodes
Biopsy
Therapeutics
Infection
Neoplasms

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Fatal eosinophilic disease following autologous bone marrow transplantation. / Gross, T. G.; Hoge, F. J.; Jackson, J. D.; Sammut, Paul Henry; Warkentin, Phyllis Irene.

In: Bone marrow transplantation, Vol. 14, No. 2, 01.01.1994, p. 333-337.

Research output: Contribution to journalArticle

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