Fat-soluble nutrients and Omega-3 fatty acids as modifiable factors influencing preterm birth risk

Melissa Thoene, Matthew Van Ormer, Ana Yuil-Valdes, Taylor Bruett, Sathish Kumar Natarajan, Maheswari Mukherjee, Maranda Thompson, Tara M. Nordgren, Wendy Van Lippevelde, Nina C. Overby, Kwame Adu-Bonsaffoh, Ann Anderson-Berry, Corrine Hanson

Research output: Contribution to journalReview article

Abstract

Preterm birth is a leading cause of child morbidity and mortality, so strategies to reduce early birth must remain a priority. One key approach to enhancing birth outcomes is improving maternal dietary intake. Therefore, the purpose of this review is to discuss mechanisms on perinatal status of fat-soluble nutrients (carotenoids, retinol, tocopherols) and omega-3 fatty acids and how they impact risk for preterm birth. Literature review demonstrates that maternal dietary intake and biological (blood and placental tissue) levels of fat-soluble nutrients during pregnancy may provide antioxidative, anti-inflammatory, and immunomodulatory health benefits. Omega-3 fatty acids also promote increased production of specialized pro-resolving mediators, subsequently mediating inflammation resolution. Combined effects of these nutrients support appropriate placental organogenesis and function. Consequently, fat-soluble nutrients and omega-3 fatty acids serve as strong influencers for preterm birth risk. As dietary intake remains a modifiable factor, future intervention would benefit from a focus on optimizing perinatal status of these specific nutrients.

Original languageEnglish (US)
JournalPlacenta
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Premature Birth
Omega-3 Fatty Acids
Fats
Food
Mothers
Parturition
Child Mortality
Tocopherols
Organogenesis
Insurance Benefits
Carotenoids
Vitamin A
Anti-Inflammatory Agents
Inflammation
Morbidity
Pregnancy

Keywords

  • Carotenoid
  • Omega-3
  • Placenta
  • Preterm birth
  • Retinol
  • Tocopherol

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

Cite this

Fat-soluble nutrients and Omega-3 fatty acids as modifiable factors influencing preterm birth risk. / Thoene, Melissa; Van Ormer, Matthew; Yuil-Valdes, Ana; Bruett, Taylor; Natarajan, Sathish Kumar; Mukherjee, Maheswari; Thompson, Maranda; Nordgren, Tara M.; Van Lippevelde, Wendy; Overby, Nina C.; Adu-Bonsaffoh, Kwame; Anderson-Berry, Ann; Hanson, Corrine.

In: Placenta, 01.01.2019.

Research output: Contribution to journalReview article

Thoene, M, Van Ormer, M, Yuil-Valdes, A, Bruett, T, Natarajan, SK, Mukherjee, M, Thompson, M, Nordgren, TM, Van Lippevelde, W, Overby, NC, Adu-Bonsaffoh, K, Anderson-Berry, A & Hanson, C 2019, 'Fat-soluble nutrients and Omega-3 fatty acids as modifiable factors influencing preterm birth risk', Placenta. https://doi.org/10.1016/j.placenta.2019.12.002
Thoene, Melissa ; Van Ormer, Matthew ; Yuil-Valdes, Ana ; Bruett, Taylor ; Natarajan, Sathish Kumar ; Mukherjee, Maheswari ; Thompson, Maranda ; Nordgren, Tara M. ; Van Lippevelde, Wendy ; Overby, Nina C. ; Adu-Bonsaffoh, Kwame ; Anderson-Berry, Ann ; Hanson, Corrine. / Fat-soluble nutrients and Omega-3 fatty acids as modifiable factors influencing preterm birth risk. In: Placenta. 2019.
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