Fast Doppler as a novel bedside measure of cerebral perfusion in preterm infants

Eric S Peeples, Edin Mehic, Pierre D. Mourad, Sandra E. Juul

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Altered cerebral perfusion from impaired autoregulation may contribute to the morbidity and mortality associated with premature birth. We hypothesized that fast Doppler imaging could provide a reproducible bedside estimation of cerebral perfusion and autoregulation in preterm infants. Methods: This is a prospective pilot study using fast Doppler ultrasound to assess blood flow velocity in the basal ganglia of 19 subjects born at 26-32 wk gestation. Intraclass correlation provided a measure of test-retest reliability, and linear regression of cerebral blood flow velocity and heart rate or blood pressure allowed for estimations of autoregulatory ability. Results: The intraclass correlation when imaging in the first 48 h of life was 0.634. We found significant and independent correlations between the systolic blood flow velocity and both systolic blood pressure and heart rate (P = 0.015 and 0.012 respectively) only in the 26-28 wk gestational age infants in the first 48 h of life. Conclusion: Our results suggest that fast Doppler provides reliable bedside measurements of cerebral blood flow velocity at the tissue level in premature infants, acting as a proxy for cerebral tissue perfusion. Additionally, autoregulation appears to be impaired in the extremely preterm infants, even within a normal range of blood pressures.

Original languageEnglish (US)
Pages (from-to)333-338
Number of pages6
JournalPediatric Research
Volume79
Issue number2
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

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Blood Flow Velocity
Premature Infants
Cerebrovascular Circulation
Perfusion
Blood Pressure
Homeostasis
Heart Rate
Extremely Premature Infants
Doppler Ultrasonography
Premature Birth
Proxy
Basal Ganglia
Reproducibility of Results
Gestational Age
Linear Models
Reference Values
Prospective Studies
Morbidity
Pregnancy
Mortality

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Fast Doppler as a novel bedside measure of cerebral perfusion in preterm infants. / Peeples, Eric S; Mehic, Edin; Mourad, Pierre D.; Juul, Sandra E.

In: Pediatric Research, Vol. 79, No. 2, 01.03.2016, p. 333-338.

Research output: Contribution to journalArticle

Peeples, Eric S ; Mehic, Edin ; Mourad, Pierre D. ; Juul, Sandra E. / Fast Doppler as a novel bedside measure of cerebral perfusion in preterm infants. In: Pediatric Research. 2016 ; Vol. 79, No. 2. pp. 333-338.
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