Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum

Daniel D. Mosel, Raluca Dumitru, Jacob M. Hornby, Audrey L. Atkin, Kenneth W. Nickerson

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 μM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 μM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.

Original languageEnglish (US)
Pages (from-to)4938-4940
Number of pages3
JournalApplied and environmental microbiology
Volume71
Issue number8
DOIs
StatePublished - Aug 1 2005

Fingerprint

Farnesol
farnesol
germ tube
Candida albicans
serum
Serum
germination
Germination
germ

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

Cite this

Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum. / Mosel, Daniel D.; Dumitru, Raluca; Hornby, Jacob M.; Atkin, Audrey L.; Nickerson, Kenneth W.

In: Applied and environmental microbiology, Vol. 71, No. 8, 01.08.2005, p. 4938-4940.

Research output: Contribution to journalArticle

@article{6fb375bc60ab439eb40261ab1d8c24e5,
title = "Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum",
abstract = "Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 μM farnesol was sufficient. However, with serum at 2 to 20{\%}, up to 250 μM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.",
author = "Mosel, {Daniel D.} and Raluca Dumitru and Hornby, {Jacob M.} and Atkin, {Audrey L.} and Nickerson, {Kenneth W.}",
year = "2005",
month = "8",
day = "1",
doi = "10.1128/AEM.71.8.4938-4940.2005",
language = "English (US)",
volume = "71",
pages = "4938--4940",
journal = "Applied and Environmental Microbiology",
issn = "0099-2240",
publisher = "American Society for Microbiology",
number = "8",

}

TY - JOUR

T1 - Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum

AU - Mosel, Daniel D.

AU - Dumitru, Raluca

AU - Hornby, Jacob M.

AU - Atkin, Audrey L.

AU - Nickerson, Kenneth W.

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 μM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 μM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.

AB - Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 μM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 μM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.

UR - http://www.scopus.com/inward/record.url?scp=23744445246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744445246&partnerID=8YFLogxK

U2 - 10.1128/AEM.71.8.4938-4940.2005

DO - 10.1128/AEM.71.8.4938-4940.2005

M3 - Article

C2 - 16085901

AN - SCOPUS:23744445246

VL - 71

SP - 4938

EP - 4940

JO - Applied and Environmental Microbiology

JF - Applied and Environmental Microbiology

SN - 0099-2240

IS - 8

ER -