FAP, gastric cancer, and genetic counseling featuring children and young adults: A family study and review

Henry T. Lynch, Carrie Snyder, Janine M. Davies, Stephen Lanspa, Jane Lynch, Zoran Gatalica, Victoria Graeve, Jason Foster

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Familial adenomatous polyposis is a highly complex and multifaceted colorectal cancer prone disorder which is often significantly confounded by extracolonic cancers inclusive of gastric cancer, a significant problem in the Orient. Gastric cancer in familial adenomatous polyposis is heavily influenced by fundic gland polyps which are often so voluminous as to defy effective endoscopic surveillance. This study involves more than two decades of investigation of an attenuated familial adenomatous polyposis family where gastric cancer posed an early diagnostic problem because it was obscured by multiple fundic gland polyps. Fundic gland polyps are common in familial adenomatous polyposis and attenuated familial adenomatous polyposis and, if voluminous, may interfere with effective endoscopic gastric cancer surveillance. This family is believed to be the first of its type reported with focus upon education and genetic counseling in the setting of a family information service. Cancer control in familial adenomatous polyposis may be partially resolved through use of familial colorectal cancer registries, with greater attention to family history and its interpretation, genetic counseling, and clinical translation for diagnosis and management.

Original languageEnglish (US)
Pages (from-to)581-588
Number of pages8
JournalFamilial Cancer
Volume9
Issue number4
DOIs
StatePublished - Dec 1 2010

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Keywords

  • APC gene
  • Attenuated familial adenomatous polyposis
  • Familial adenomatous polyposis
  • Fundic gland polyps
  • Gastric cancer
  • Genetic counseling
  • Hereditary cancer

ASJC Scopus subject areas

  • Genetics
  • Oncology
  • Genetics(clinical)
  • Cancer Research

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