Familial canine dermatomyositis

clinicopathologic, immunologic, and serologic studies.

K. H. Haupt, D. J. Prieur, A. M. Hargis, R. L. Cowell, Thomas L McDonald, L. L. Werner, J. F. Evermann

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Laboratory studies were performed on 3 Collies with familial canine dermatomyositis, 6 progeny from a breeding of 2 of the Collies (incross litter), and 4 progeny from the breeding of an affected Collie male and a normal Labrador Retriever (outcross litter). Hematologic abnormalities were leukogram changes consistent with inflammation, and, in 2 severely affected incross dogs, anemia of inflammatory disease. Serum muscle enzyme activities were not markedly increased. High concentrations of immune complexes and proportionally increased total immunoglobulin G were present in the sera of moderately and severely affected incross dogs. The same dogs had weakly positive direct Coombs' tests, and 1 affected outcross dog had a strongly positive direct Coombs' test. Rheumatoid factor was present in a severely affected incross dog. A few dogs had polyclonal globulin increases that were attributed to inflammation. Low antibody titers to canine calicivirus were present in 3 dogs and a low titer to canine coronavirus was present in 1 dog.

Original languageEnglish (US)
Pages (from-to)1870-1875
Number of pages6
JournalAmerican journal of veterinary research
Volume46
Issue number9
StatePublished - Sep 1 1985

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dermatomyositis
Dermatomyositis
serological surveys
Canidae
Dogs
dogs
Coombs Test
Breeding
Canine Coronavirus
inflammation
Inflammation
Newfoundland and Labrador
Canine coronavirus
Collie
Rheumatoid Factor
Globulins
antigen-antibody complex
Labrador Retriever
Antigen-Antibody Complex
Serum

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Haupt, K. H., Prieur, D. J., Hargis, A. M., Cowell, R. L., McDonald, T. L., Werner, L. L., & Evermann, J. F. (1985). Familial canine dermatomyositis: clinicopathologic, immunologic, and serologic studies. American journal of veterinary research, 46(9), 1870-1875.

Familial canine dermatomyositis : clinicopathologic, immunologic, and serologic studies. / Haupt, K. H.; Prieur, D. J.; Hargis, A. M.; Cowell, R. L.; McDonald, Thomas L; Werner, L. L.; Evermann, J. F.

In: American journal of veterinary research, Vol. 46, No. 9, 01.09.1985, p. 1870-1875.

Research output: Contribution to journalArticle

Haupt, KH, Prieur, DJ, Hargis, AM, Cowell, RL, McDonald, TL, Werner, LL & Evermann, JF 1985, 'Familial canine dermatomyositis: clinicopathologic, immunologic, and serologic studies.', American journal of veterinary research, vol. 46, no. 9, pp. 1870-1875.
Haupt, K. H. ; Prieur, D. J. ; Hargis, A. M. ; Cowell, R. L. ; McDonald, Thomas L ; Werner, L. L. ; Evermann, J. F. / Familial canine dermatomyositis : clinicopathologic, immunologic, and serologic studies. In: American journal of veterinary research. 1985 ; Vol. 46, No. 9. pp. 1870-1875.
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