FAK and paxillin, two potential targets in pancreatic cancer

Rajani Kanteti, Surinder K. Batra, Frances E. Lennon, Ravi Salgia

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer in large part due to late diagnosis and a lack of effective screening tests. In spite of recent progress in imaging, surgery and new therapeutic options for pancreatic cancer, the overall five-year survival still remains unacceptably low. Numerous studies have shown that focal adhesion kinase (FAK) is activated in many cancers including PDAC and promotes cancer progression and metastasis. Paxillin, an intracellular adaptor protein that plays a key role in cytoskeletal organization, connects integrins to FAK and plays a key role in assembly and disassembly of focal adhesions. Here, we have reviewed evidence in support of FAK as a potential therapeutic target and summarized related combinatorial therapies.

Original languageEnglish (US)
Pages (from-to)31586-31601
Number of pages16
JournalOncotarget
Volume7
Issue number21
DOIs
StatePublished - May 24 2016

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Keywords

  • FAK
  • Integrins
  • P53
  • Pancreatic cancer
  • Paxillin

ASJC Scopus subject areas

  • Oncology

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