Failure of ascorbic acid to inhibit fanft induced bladder cancer

M. S. Soloway, Samuel Monroe Cohen, J. B. Dekernion, L. Persky

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

L ascorbic acid has been shown to reduce the elevated level of urinary chemiluminescence found in patients with bladder cancer. Thus, it has been suggested that vitamin C might be efficacious in bladder tumor prophylaxis. However, there is no clinical evidence to support this thesis. The authors evaluated whether L ascorbic acid given concomitantly with the urinary carcinogen N [4 (5 nitro 2 furyl) 2 thiazolyl]formamide (FANFT) was capable of reducing the incidence of subsequent bladder tumors. No inhibitory effect was observed. Unless evidence is obtained demonstrating bladder tumor prevention by L ascorbic acid its routine administration to patients with bladder cancer is not indicated.

Original languageEnglish (US)
Pages (from-to)483-486
Number of pages4
JournalJournal of Urology
Volume113
Issue number4
DOIs
StatePublished - Jan 1 1975

Fingerprint

Urinary Bladder Neoplasms
Ascorbic Acid
FANFT
Luminescence
Carcinogens
Incidence

ASJC Scopus subject areas

  • Urology

Cite this

Failure of ascorbic acid to inhibit fanft induced bladder cancer. / Soloway, M. S.; Cohen, Samuel Monroe; Dekernion, J. B.; Persky, L.

In: Journal of Urology, Vol. 113, No. 4, 01.01.1975, p. 483-486.

Research output: Contribution to journalArticle

Soloway, M. S. ; Cohen, Samuel Monroe ; Dekernion, J. B. ; Persky, L. / Failure of ascorbic acid to inhibit fanft induced bladder cancer. In: Journal of Urology. 1975 ; Vol. 113, No. 4. pp. 483-486.
@article{917ad999c9484bb780664ee1c17eb4b1,
title = "Failure of ascorbic acid to inhibit fanft induced bladder cancer",
abstract = "L ascorbic acid has been shown to reduce the elevated level of urinary chemiluminescence found in patients with bladder cancer. Thus, it has been suggested that vitamin C might be efficacious in bladder tumor prophylaxis. However, there is no clinical evidence to support this thesis. The authors evaluated whether L ascorbic acid given concomitantly with the urinary carcinogen N [4 (5 nitro 2 furyl) 2 thiazolyl]formamide (FANFT) was capable of reducing the incidence of subsequent bladder tumors. No inhibitory effect was observed. Unless evidence is obtained demonstrating bladder tumor prevention by L ascorbic acid its routine administration to patients with bladder cancer is not indicated.",
author = "Soloway, {M. S.} and Cohen, {Samuel Monroe} and Dekernion, {J. B.} and L. Persky",
year = "1975",
month = "1",
day = "1",
doi = "10.1016/S0022-5347(17)59506-3",
language = "English (US)",
volume = "113",
pages = "483--486",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Failure of ascorbic acid to inhibit fanft induced bladder cancer

AU - Soloway, M. S.

AU - Cohen, Samuel Monroe

AU - Dekernion, J. B.

AU - Persky, L.

PY - 1975/1/1

Y1 - 1975/1/1

N2 - L ascorbic acid has been shown to reduce the elevated level of urinary chemiluminescence found in patients with bladder cancer. Thus, it has been suggested that vitamin C might be efficacious in bladder tumor prophylaxis. However, there is no clinical evidence to support this thesis. The authors evaluated whether L ascorbic acid given concomitantly with the urinary carcinogen N [4 (5 nitro 2 furyl) 2 thiazolyl]formamide (FANFT) was capable of reducing the incidence of subsequent bladder tumors. No inhibitory effect was observed. Unless evidence is obtained demonstrating bladder tumor prevention by L ascorbic acid its routine administration to patients with bladder cancer is not indicated.

AB - L ascorbic acid has been shown to reduce the elevated level of urinary chemiluminescence found in patients with bladder cancer. Thus, it has been suggested that vitamin C might be efficacious in bladder tumor prophylaxis. However, there is no clinical evidence to support this thesis. The authors evaluated whether L ascorbic acid given concomitantly with the urinary carcinogen N [4 (5 nitro 2 furyl) 2 thiazolyl]formamide (FANFT) was capable of reducing the incidence of subsequent bladder tumors. No inhibitory effect was observed. Unless evidence is obtained demonstrating bladder tumor prevention by L ascorbic acid its routine administration to patients with bladder cancer is not indicated.

UR - http://www.scopus.com/inward/record.url?scp=0016740977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016740977&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(17)59506-3

DO - 10.1016/S0022-5347(17)59506-3

M3 - Article

VL - 113

SP - 483

EP - 486

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 4

ER -