Factors in the development of liver transplantation

T. E. Starzl, S. Iwatsuki, B. W. Shaw

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Liver transplantation has become an accepted service during the last five years. The introduction of cyclosporine-steroid therapy has been the most important factor in making this possible. Improvements in surgical technique, including perfection of intraoperative venovenous bypasses and the standardization of biliary tract reconstruction have also contributed. Tissue typing and matching have played no role in improving the results of liver transplantation. With the demonstration that preformed antibody states are irrelevant, even avoidance of positive cross-matches caused by cytotoxic antibodies and observance of ABO blood group barriers have become unnecessary if the recipient's needs are great. The nature of the underlying hepatic disease has not profoundly influenced the results, with the exceptions of malignancy and cirrhosis. Retransplantation has played an important role in improving survival. The development of better methods of preservation that will allow the recipient operations to be done in a more leisurely manner and at more convenient times is the most pressing need for further application of liver transplantation at a national and international level.

Original languageEnglish (US)
Pages (from-to)107-119
Number of pages13
JournalTransplantation Proceedings
Volume17
Issue numberSUPPL. 2
StatePublished - Jan 1 1985

Fingerprint

Liver Transplantation
Histocompatibility Testing
Antibodies
Biliary Tract
Blood Group Antigens
Cyclosporine
Fibrosis
Steroids
Liver
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Starzl, T. E., Iwatsuki, S., & Shaw, B. W. (1985). Factors in the development of liver transplantation. Transplantation Proceedings, 17(SUPPL. 2), 107-119.

Factors in the development of liver transplantation. / Starzl, T. E.; Iwatsuki, S.; Shaw, B. W.

In: Transplantation Proceedings, Vol. 17, No. SUPPL. 2, 01.01.1985, p. 107-119.

Research output: Contribution to journalArticle

Starzl, TE, Iwatsuki, S & Shaw, BW 1985, 'Factors in the development of liver transplantation', Transplantation Proceedings, vol. 17, no. SUPPL. 2, pp. 107-119.
Starzl TE, Iwatsuki S, Shaw BW. Factors in the development of liver transplantation. Transplantation Proceedings. 1985 Jan 1;17(SUPPL. 2):107-119.
Starzl, T. E. ; Iwatsuki, S. ; Shaw, B. W. / Factors in the development of liver transplantation. In: Transplantation Proceedings. 1985 ; Vol. 17, No. SUPPL. 2. pp. 107-119.
@article{f3dd378d0a714d728a5563bd5ae31f39,
title = "Factors in the development of liver transplantation",
abstract = "Liver transplantation has become an accepted service during the last five years. The introduction of cyclosporine-steroid therapy has been the most important factor in making this possible. Improvements in surgical technique, including perfection of intraoperative venovenous bypasses and the standardization of biliary tract reconstruction have also contributed. Tissue typing and matching have played no role in improving the results of liver transplantation. With the demonstration that preformed antibody states are irrelevant, even avoidance of positive cross-matches caused by cytotoxic antibodies and observance of ABO blood group barriers have become unnecessary if the recipient's needs are great. The nature of the underlying hepatic disease has not profoundly influenced the results, with the exceptions of malignancy and cirrhosis. Retransplantation has played an important role in improving survival. The development of better methods of preservation that will allow the recipient operations to be done in a more leisurely manner and at more convenient times is the most pressing need for further application of liver transplantation at a national and international level.",
author = "Starzl, {T. E.} and S. Iwatsuki and Shaw, {B. W.}",
year = "1985",
month = "1",
day = "1",
language = "English (US)",
volume = "17",
pages = "107--119",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Factors in the development of liver transplantation

AU - Starzl, T. E.

AU - Iwatsuki, S.

AU - Shaw, B. W.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Liver transplantation has become an accepted service during the last five years. The introduction of cyclosporine-steroid therapy has been the most important factor in making this possible. Improvements in surgical technique, including perfection of intraoperative venovenous bypasses and the standardization of biliary tract reconstruction have also contributed. Tissue typing and matching have played no role in improving the results of liver transplantation. With the demonstration that preformed antibody states are irrelevant, even avoidance of positive cross-matches caused by cytotoxic antibodies and observance of ABO blood group barriers have become unnecessary if the recipient's needs are great. The nature of the underlying hepatic disease has not profoundly influenced the results, with the exceptions of malignancy and cirrhosis. Retransplantation has played an important role in improving survival. The development of better methods of preservation that will allow the recipient operations to be done in a more leisurely manner and at more convenient times is the most pressing need for further application of liver transplantation at a national and international level.

AB - Liver transplantation has become an accepted service during the last five years. The introduction of cyclosporine-steroid therapy has been the most important factor in making this possible. Improvements in surgical technique, including perfection of intraoperative venovenous bypasses and the standardization of biliary tract reconstruction have also contributed. Tissue typing and matching have played no role in improving the results of liver transplantation. With the demonstration that preformed antibody states are irrelevant, even avoidance of positive cross-matches caused by cytotoxic antibodies and observance of ABO blood group barriers have become unnecessary if the recipient's needs are great. The nature of the underlying hepatic disease has not profoundly influenced the results, with the exceptions of malignancy and cirrhosis. Retransplantation has played an important role in improving survival. The development of better methods of preservation that will allow the recipient operations to be done in a more leisurely manner and at more convenient times is the most pressing need for further application of liver transplantation at a national and international level.

UR - http://www.scopus.com/inward/record.url?scp=0022357935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022357935&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0022357935

VL - 17

SP - 107

EP - 119

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - SUPPL. 2

ER -