Factors affecting radioactive microsphere measurement of blood flow in pregnant guinea pigs.

S. Myers, John W Sparks, E. L. Makowski

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Comparative blood flow studies were performed in pregnant guinea pigs using radioactive microspheres to test the effects of different sphere sizes on blood flow measurements and the relationship between flows obtained intraoperatively and those performed after 5 days of recovery from anesthesia and surgery. We observed that 1.5% of the cardiac output was shunted through the microcirculation of the carcass, gut, skin and endomyometrium when 15 mu microspheres were used. Intraoperative measurements of heart rate, cardiac output and placental blood flow are significantly lower than measurements made after 5 days recovery. These reductions were ameliorated with the addition of a continuous infusion of isoproterenol and the deletion of atropine from the anesthetic.

Original languageEnglish (US)
Pages (from-to)522-526
Number of pages5
JournalLaboratory animal science
Volume36
Issue number5
StatePublished - Oct 1 1986

Fingerprint

Microspheres
guinea pigs
blood flow
Guinea Pigs
Blood
cardiac output
Cardiac Output
Microcirculation
Recovery
atropine
Flow measurement
Atropine
Isoproterenol
skin (animal)
anesthetics
Surgery
Anesthetics
heart rate
anesthesia
Skin

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Factors affecting radioactive microsphere measurement of blood flow in pregnant guinea pigs. / Myers, S.; Sparks, John W; Makowski, E. L.

In: Laboratory animal science, Vol. 36, No. 5, 01.10.1986, p. 522-526.

Research output: Contribution to journalArticle

@article{c752b0d3ab0a44c28d13448c229e7e7d,
title = "Factors affecting radioactive microsphere measurement of blood flow in pregnant guinea pigs.",
abstract = "Comparative blood flow studies were performed in pregnant guinea pigs using radioactive microspheres to test the effects of different sphere sizes on blood flow measurements and the relationship between flows obtained intraoperatively and those performed after 5 days of recovery from anesthesia and surgery. We observed that 1.5{\%} of the cardiac output was shunted through the microcirculation of the carcass, gut, skin and endomyometrium when 15 mu microspheres were used. Intraoperative measurements of heart rate, cardiac output and placental blood flow are significantly lower than measurements made after 5 days recovery. These reductions were ameliorated with the addition of a continuous infusion of isoproterenol and the deletion of atropine from the anesthetic.",
author = "S. Myers and Sparks, {John W} and Makowski, {E. L.}",
year = "1986",
month = "10",
day = "1",
language = "English (US)",
volume = "36",
pages = "522--526",
journal = "Comparative Medicine",
issn = "1532-0820",
publisher = "American Association for Laboratory Animal Science",
number = "5",

}

TY - JOUR

T1 - Factors affecting radioactive microsphere measurement of blood flow in pregnant guinea pigs.

AU - Myers, S.

AU - Sparks, John W

AU - Makowski, E. L.

PY - 1986/10/1

Y1 - 1986/10/1

N2 - Comparative blood flow studies were performed in pregnant guinea pigs using radioactive microspheres to test the effects of different sphere sizes on blood flow measurements and the relationship between flows obtained intraoperatively and those performed after 5 days of recovery from anesthesia and surgery. We observed that 1.5% of the cardiac output was shunted through the microcirculation of the carcass, gut, skin and endomyometrium when 15 mu microspheres were used. Intraoperative measurements of heart rate, cardiac output and placental blood flow are significantly lower than measurements made after 5 days recovery. These reductions were ameliorated with the addition of a continuous infusion of isoproterenol and the deletion of atropine from the anesthetic.

AB - Comparative blood flow studies were performed in pregnant guinea pigs using radioactive microspheres to test the effects of different sphere sizes on blood flow measurements and the relationship between flows obtained intraoperatively and those performed after 5 days of recovery from anesthesia and surgery. We observed that 1.5% of the cardiac output was shunted through the microcirculation of the carcass, gut, skin and endomyometrium when 15 mu microspheres were used. Intraoperative measurements of heart rate, cardiac output and placental blood flow are significantly lower than measurements made after 5 days recovery. These reductions were ameliorated with the addition of a continuous infusion of isoproterenol and the deletion of atropine from the anesthetic.

UR - http://www.scopus.com/inward/record.url?scp=0022791821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022791821&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 522

EP - 526

JO - Comparative Medicine

JF - Comparative Medicine

SN - 1532-0820

IS - 5

ER -