Facilitation by drug states does not depend on acquired excitatory strength

Matthew I. Palmatier, Rick A Bevins

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Three experiments examined the effects of drug-extinction when a drug state served as a conditional stimulus (CS) for sucrose delivery or as a positive feature for pairings between a discrete CS (e.g., 15-s light-on) and sucrose. Some conditioning models predict that drug state will facilitate the conditional response (CR) based on an association with sucrose whether the drug is trained as a CS or as a facilitator. If so, repeated presentation of the drug state alone (drug-extinction) should decrease the CR in both situations. Nicotine (0.4 mg/kg), amphetamine (AMP, 1 mg/kg), and chlordiazepoxide (CDP, 5 mg/kg) facilitated a goal tracking conditioned response to the discrete CS; however, AMP and CDP did not evoke reliable responding without an interposed stimulus, suggesting that associations between these drug states and sucrose are not expressed as anticipatory food seeking (goal tracking). Repeated presentation of each drug state alone did not disrupt facilitation by nicotine, amphetamine, or CDP; suggesting that the drug states did not facilitate goal tracking based on a direct association with sucrose. This latter finding implicates a higher-order or non-associative mechanism for facilitation of anticipatory food seeking by drug states in this Pavlovian discrimination task.

Original languageEnglish (US)
Pages (from-to)292-301
Number of pages10
JournalBehavioural Brain Research
Volume176
Issue number2
DOIs
StatePublished - Jan 25 2007

Fingerprint

Pharmaceutical Preparations
Sucrose
Cytidine Diphosphate
Amphetamine
Adenosine Monophosphate
Nicotine
Chlordiazepoxide
Food
Light

Keywords

  • Addiction
  • Drug abuse
  • Learning
  • Motivation
  • Occasion setting
  • Pavlovian conditioning

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Facilitation by drug states does not depend on acquired excitatory strength. / Palmatier, Matthew I.; Bevins, Rick A.

In: Behavioural Brain Research, Vol. 176, No. 2, 25.01.2007, p. 292-301.

Research output: Contribution to journalArticle

@article{f7113ac5f6f041098f4b7778309ffb63,
title = "Facilitation by drug states does not depend on acquired excitatory strength",
abstract = "Three experiments examined the effects of drug-extinction when a drug state served as a conditional stimulus (CS) for sucrose delivery or as a positive feature for pairings between a discrete CS (e.g., 15-s light-on) and sucrose. Some conditioning models predict that drug state will facilitate the conditional response (CR) based on an association with sucrose whether the drug is trained as a CS or as a facilitator. If so, repeated presentation of the drug state alone (drug-extinction) should decrease the CR in both situations. Nicotine (0.4 mg/kg), amphetamine (AMP, 1 mg/kg), and chlordiazepoxide (CDP, 5 mg/kg) facilitated a goal tracking conditioned response to the discrete CS; however, AMP and CDP did not evoke reliable responding without an interposed stimulus, suggesting that associations between these drug states and sucrose are not expressed as anticipatory food seeking (goal tracking). Repeated presentation of each drug state alone did not disrupt facilitation by nicotine, amphetamine, or CDP; suggesting that the drug states did not facilitate goal tracking based on a direct association with sucrose. This latter finding implicates a higher-order or non-associative mechanism for facilitation of anticipatory food seeking by drug states in this Pavlovian discrimination task.",
keywords = "Addiction, Drug abuse, Learning, Motivation, Occasion setting, Pavlovian conditioning",
author = "Palmatier, {Matthew I.} and Bevins, {Rick A}",
year = "2007",
month = "1",
day = "25",
doi = "10.1016/j.bbr.2006.10.015",
language = "English (US)",
volume = "176",
pages = "292--301",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Facilitation by drug states does not depend on acquired excitatory strength

AU - Palmatier, Matthew I.

AU - Bevins, Rick A

PY - 2007/1/25

Y1 - 2007/1/25

N2 - Three experiments examined the effects of drug-extinction when a drug state served as a conditional stimulus (CS) for sucrose delivery or as a positive feature for pairings between a discrete CS (e.g., 15-s light-on) and sucrose. Some conditioning models predict that drug state will facilitate the conditional response (CR) based on an association with sucrose whether the drug is trained as a CS or as a facilitator. If so, repeated presentation of the drug state alone (drug-extinction) should decrease the CR in both situations. Nicotine (0.4 mg/kg), amphetamine (AMP, 1 mg/kg), and chlordiazepoxide (CDP, 5 mg/kg) facilitated a goal tracking conditioned response to the discrete CS; however, AMP and CDP did not evoke reliable responding without an interposed stimulus, suggesting that associations between these drug states and sucrose are not expressed as anticipatory food seeking (goal tracking). Repeated presentation of each drug state alone did not disrupt facilitation by nicotine, amphetamine, or CDP; suggesting that the drug states did not facilitate goal tracking based on a direct association with sucrose. This latter finding implicates a higher-order or non-associative mechanism for facilitation of anticipatory food seeking by drug states in this Pavlovian discrimination task.

AB - Three experiments examined the effects of drug-extinction when a drug state served as a conditional stimulus (CS) for sucrose delivery or as a positive feature for pairings between a discrete CS (e.g., 15-s light-on) and sucrose. Some conditioning models predict that drug state will facilitate the conditional response (CR) based on an association with sucrose whether the drug is trained as a CS or as a facilitator. If so, repeated presentation of the drug state alone (drug-extinction) should decrease the CR in both situations. Nicotine (0.4 mg/kg), amphetamine (AMP, 1 mg/kg), and chlordiazepoxide (CDP, 5 mg/kg) facilitated a goal tracking conditioned response to the discrete CS; however, AMP and CDP did not evoke reliable responding without an interposed stimulus, suggesting that associations between these drug states and sucrose are not expressed as anticipatory food seeking (goal tracking). Repeated presentation of each drug state alone did not disrupt facilitation by nicotine, amphetamine, or CDP; suggesting that the drug states did not facilitate goal tracking based on a direct association with sucrose. This latter finding implicates a higher-order or non-associative mechanism for facilitation of anticipatory food seeking by drug states in this Pavlovian discrimination task.

KW - Addiction

KW - Drug abuse

KW - Learning

KW - Motivation

KW - Occasion setting

KW - Pavlovian conditioning

UR - http://www.scopus.com/inward/record.url?scp=33845329563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845329563&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2006.10.015

DO - 10.1016/j.bbr.2006.10.015

M3 - Article

VL - 176

SP - 292

EP - 301

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 2

ER -