Fabrication of injectable and superelastic nanofiber rectangle matrices (“peanuts”) and their potential applications in hemostasis

Shixuan Chen, Mark Alan Carlson, Yu Shrike Zhang, Yong Hu, Jingwei Xie

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Uncontrolled hemorrhage, which typically involves the torso and/or limb junctional zones, remains a great challenge in the prehospital setting. Here, we for the first time report an injectable and superelastic nanofiber rectangle matrix (“peanut”) fabricated by a combination of electrospinning, gas foaming, hydrogel coating and crosslinking techniques. The compressed nanofiber peanut is capable of re-expanding to its original shape in atmosphere, water and blood within 10 s. Such nanofiber peanuts exhibit greater capacity of water/blood absorption compared to current commercial products and high efficacy in whole blood clotting assay, in particular for thrombin-immobilized samples. These nanofiber peanuts are capable of being packed into a syringe for injection. Further in vivo tests indicated the effectiveness of nanofiber peanuts for hemostasis in a porcine liver injury model. This new class of nanofiber-based materials may hold great promise for hemostatic applications.

Original languageEnglish (US)
Pages (from-to)46-59
Number of pages14
JournalBiomaterials
Volume179
DOIs
StatePublished - Oct 1 2018

Fingerprint

Nanofibers
Hemostasis
Fabrication
Injections
Blood
Gas foaming
Syringes
Torso
Water
Hydrogel
Electrospinning
Blood Coagulation
Hemostatics
Atmosphere
Hydrogels
Thrombin
Liver
Crosslinking
Arachis
Assays

Keywords

  • Electrospinning
  • Hemostasis
  • Injectable
  • Nanofiber rectangle matrix
  • Superelastic

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Fabrication of injectable and superelastic nanofiber rectangle matrices (“peanuts”) and their potential applications in hemostasis. / Chen, Shixuan; Carlson, Mark Alan; Zhang, Yu Shrike; Hu, Yong; Xie, Jingwei.

In: Biomaterials, Vol. 179, 01.10.2018, p. 46-59.

Research output: Contribution to journalArticle

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