Fabrication of assembled virus nanostructures on templates of chemoselective linkers formed by scanning probe nanolithography

Chin Li Cheung, Julio A. Camarero, Bruce W. Woods, Tianwei Lin, John E. Johnson, Jim J. De Yoreo

Research output: Contribution to journalArticle

150 Scopus citations


We have developed a multistep route to the fabrication of virus assembled nanostructures with chemoselective protein-to-surface linkers synthesized by an efficient solid-phase method. These linkers were used to create patterns of 30-to-50-nm-width-lines by scanning probe nanolithography. Genetically modified cow pea mosaic virus with unique cysteine residues at specific locations on their capsomers were assembled through covalent linkage on these patterns. The morphology of the assembled structures on these line patterns characterized by atomic force microscopy was found to be strongly influenced by the intervirion interactions.

Original languageEnglish (US)
Pages (from-to)6848-6849
Number of pages2
JournalJournal of the American Chemical Society
Issue number23
StatePublished - Jun 11 2003


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this