Fabrication of assembled virus nanostructures on templates of chemoselective linkers formed by scanning probe nanolithography

Chin Li Cheung, Julio A. Camarero, Bruce W. Woods, Tianwei Lin, John E. Johnson, Jim J. De Yoreo

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

We have developed a multistep route to the fabrication of virus assembled nanostructures with chemoselective protein-to-surface linkers synthesized by an efficient solid-phase method. These linkers were used to create patterns of 30-to-50-nm-width-lines by scanning probe nanolithography. Genetically modified cow pea mosaic virus with unique cysteine residues at specific locations on their capsomers were assembled through covalent linkage on these patterns. The morphology of the assembled structures on these line patterns characterized by atomic force microscopy was found to be strongly influenced by the intervirion interactions.

Original languageEnglish (US)
Pages (from-to)6848-6849
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number23
DOIs
StatePublished - Jun 11 2003

Fingerprint

Nanolithography
Mosaic Viruses
Nanostructures
Atomic Force Microscopy
Peas
Viruses
Cysteine
Membrane Proteins
Scanning
Fabrication
Atomic force microscopy
Proteins

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Fabrication of assembled virus nanostructures on templates of chemoselective linkers formed by scanning probe nanolithography. / Cheung, Chin Li; Camarero, Julio A.; Woods, Bruce W.; Lin, Tianwei; Johnson, John E.; De Yoreo, Jim J.

In: Journal of the American Chemical Society, Vol. 125, No. 23, 11.06.2003, p. 6848-6849.

Research output: Contribution to journalArticle

Cheung, Chin Li ; Camarero, Julio A. ; Woods, Bruce W. ; Lin, Tianwei ; Johnson, John E. ; De Yoreo, Jim J. / Fabrication of assembled virus nanostructures on templates of chemoselective linkers formed by scanning probe nanolithography. In: Journal of the American Chemical Society. 2003 ; Vol. 125, No. 23. pp. 6848-6849.
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