F-18-fluoro-deoxy-glucose positron emission tomography in the assessment of peripheral T-cell lymphomas

S. Bishu, J. M. Quigley, J. Schmitz, S. R. Bishu, R. A. Stemm, S. M. Olsasky, S. Paknikar, K. H. Holdeman, James Olen Armitage, J. H. Hankins

Research output: Contribution to journalArticle

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Abstract

F-18-fluoro-deoxy-glucose positron emission tomography (PET) is highly sensitive and specific in the imaging of B-cell lymphomas. In contrast, its utility in the diagnostic evaluation of T-cell lymphomas is less defined. In this article, we present our finding utilizing PET in peripheral T-cell lymphomas (PTCL). A retrospective review of patients who underwent PET examinations at our institution produced 24 PET examinations among patients with PTCL. A lesion-based analysis was undertaken to evaluate the diagnostic accuracy of PET in PTCL. PET findings were compared with a standard of reference and sensitivity, specificity, positive and negative predictive values were calculated. PET had an overall sensitivity of 86% and specificity of 100%. PET had high sensitivity (95%) at nodal and non-cutaneous extra-nodal sites and poor sensitivity (13%) at cutaneous sites. The mean SUV of abnormal foci in anaplastic large cell lymphoma was 11mg/ml (range: 3-40), and PTCL-unclassified was 8mg/ml (range: 1-23).

Original languageEnglish (US)
Pages (from-to)1531-1538
Number of pages8
JournalLeukemia and Lymphoma
Volume48
Issue number8
DOIs
StatePublished - Aug 1 2007

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Peripheral T-Cell Lymphoma
Positron-Emission Tomography
Glucose
Anaplastic Large-Cell Lymphoma
Sensitivity and Specificity
T-Cell Lymphoma
B-Cell Lymphoma
Skin

Keywords

  • Diagnostic accuracy
  • PET
  • PTCL

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Bishu, S., Quigley, J. M., Schmitz, J., Bishu, S. R., Stemm, R. A., Olsasky, S. M., ... Hankins, J. H. (2007). F-18-fluoro-deoxy-glucose positron emission tomography in the assessment of peripheral T-cell lymphomas. Leukemia and Lymphoma, 48(8), 1531-1538. https://doi.org/10.1080/10428190701344915

F-18-fluoro-deoxy-glucose positron emission tomography in the assessment of peripheral T-cell lymphomas. / Bishu, S.; Quigley, J. M.; Schmitz, J.; Bishu, S. R.; Stemm, R. A.; Olsasky, S. M.; Paknikar, S.; Holdeman, K. H.; Armitage, James Olen; Hankins, J. H.

In: Leukemia and Lymphoma, Vol. 48, No. 8, 01.08.2007, p. 1531-1538.

Research output: Contribution to journalArticle

Bishu, S, Quigley, JM, Schmitz, J, Bishu, SR, Stemm, RA, Olsasky, SM, Paknikar, S, Holdeman, KH, Armitage, JO & Hankins, JH 2007, 'F-18-fluoro-deoxy-glucose positron emission tomography in the assessment of peripheral T-cell lymphomas', Leukemia and Lymphoma, vol. 48, no. 8, pp. 1531-1538. https://doi.org/10.1080/10428190701344915
Bishu, S. ; Quigley, J. M. ; Schmitz, J. ; Bishu, S. R. ; Stemm, R. A. ; Olsasky, S. M. ; Paknikar, S. ; Holdeman, K. H. ; Armitage, James Olen ; Hankins, J. H. / F-18-fluoro-deoxy-glucose positron emission tomography in the assessment of peripheral T-cell lymphomas. In: Leukemia and Lymphoma. 2007 ; Vol. 48, No. 8. pp. 1531-1538.
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