Extracellular nucleotide regulation and signaling in cardiac fibrosis

Tatiana Novitskaya, Elena Chepurko, Roman Covarrubias, Sergey Novitskiy, Sergey V. Ryzhov, Igor Feoktistov, Richard J. Gumina

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Following myocardial infarction, purinergic nucleotides and nucleosides are released via non-specific and specific mechanisms in response to cellular activation, stress, or injury. These extracellular nucleotides are potent mediators of physiologic and pathologic responses, contributing to the inflammatory and fibrotic milieu within the injured myocardium. Via autocrine or paracrine signaling, cell-specific effects occur through differentially expressed purinergic receptors of the P2X, P2Y, and P1 families. Nucleotide activation of the ionotropic (ligand-gated) purine receptors (P2X) and several of the metabotropic (G-protein-coupled) purine receptors (P2Y) or adenosine activation of the P1 receptors can have profound effects on inflammatory cell function, fibroblast function, and cardiomyocyte function. Extracellular nucleotidases that hydrolyze released nucleotides regulate the magnitude and duration of purinergic signaling. While there are numerous studies on the role of the purinergic signaling pathway in cardiovascular disease, the extent to which the purinergic signaling pathway modulates cardiac fibrosis is incompletely understood. Here we provide an overview of the current understanding of how the purinergic signaling pathway modulates cardiac fibroblast function and myocardial fibrosis.

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalJournal of Molecular and Cellular Cardiology
Volume93
DOIs
StatePublished - Apr 1 2016

Fingerprint

Fibrosis
Nucleotides
Purinergic Receptors
Nucleotidases
Purinergic P2Y Receptors
Purinergic P2X Receptors
Fibroblasts
Autocrine Communication
Paracrine Communication
Purinergic P1 Receptors
G-Protein-Coupled Receptors
Nucleosides
Cardiac Myocytes
Adenosine
Myocardium
Cardiovascular Diseases
Myocardial Infarction
Ligands
Wounds and Injuries

Keywords

  • Adenosine
  • Adenosine triphosphate
  • Cardiac fibrosis
  • Ectonucleotidase
  • Purinergic receptors

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

Novitskaya, T., Chepurko, E., Covarrubias, R., Novitskiy, S., Ryzhov, S. V., Feoktistov, I., & Gumina, R. J. (2016). Extracellular nucleotide regulation and signaling in cardiac fibrosis. Journal of Molecular and Cellular Cardiology, 93, 47-56. https://doi.org/10.1016/j.yjmcc.2016.02.010

Extracellular nucleotide regulation and signaling in cardiac fibrosis. / Novitskaya, Tatiana; Chepurko, Elena; Covarrubias, Roman; Novitskiy, Sergey; Ryzhov, Sergey V.; Feoktistov, Igor; Gumina, Richard J.

In: Journal of Molecular and Cellular Cardiology, Vol. 93, 01.04.2016, p. 47-56.

Research output: Contribution to journalReview article

Novitskaya, T, Chepurko, E, Covarrubias, R, Novitskiy, S, Ryzhov, SV, Feoktistov, I & Gumina, RJ 2016, 'Extracellular nucleotide regulation and signaling in cardiac fibrosis', Journal of Molecular and Cellular Cardiology, vol. 93, pp. 47-56. https://doi.org/10.1016/j.yjmcc.2016.02.010
Novitskaya T, Chepurko E, Covarrubias R, Novitskiy S, Ryzhov SV, Feoktistov I et al. Extracellular nucleotide regulation and signaling in cardiac fibrosis. Journal of Molecular and Cellular Cardiology. 2016 Apr 1;93:47-56. https://doi.org/10.1016/j.yjmcc.2016.02.010
Novitskaya, Tatiana ; Chepurko, Elena ; Covarrubias, Roman ; Novitskiy, Sergey ; Ryzhov, Sergey V. ; Feoktistov, Igor ; Gumina, Richard J. / Extracellular nucleotide regulation and signaling in cardiac fibrosis. In: Journal of Molecular and Cellular Cardiology. 2016 ; Vol. 93. pp. 47-56.
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