Extracellular matrix and fibroblast communication following myocardial infarction

Yonggang Ma, Ganesh V. Halade, Merry L. Lindsey

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The extracellular matrix (ECM) provides structural support by serving as a scaffold for cells, and as such the ECM maintains normal tissue homeostasis and mediates the repair response following injury. In response to myocardial infarction (MI), ECM expression is generally upregulated in the left ventricle (LV), which regulates LV remodeling by modulating scar formation. The ECM directly affects scar formation by regulating growth factor release and cell adhesion and indirectly affects scar formation by regulating the inflammatory, angiogenic, and fibroblast responses. This review summarizes the current literature on ECM expression patterns and fibroblast mechanisms in the myocardium, focusing on the ECM response to MI. In addition, we discuss future research areas that are needed to better understand the molecular mechanisms of ECM action, both in general and as a means to optimize infarct healing.

Original languageEnglish (US)
Pages (from-to)848-857
Number of pages10
JournalJournal of Cardiovascular Translational Research
Volume5
Issue number6
DOIs
StatePublished - Dec 1 2012

Fingerprint

Extracellular Matrix
Fibroblasts
Myocardial Infarction
Cicatrix
Ventricular Remodeling
Cell Adhesion
Heart Ventricles
Intercellular Signaling Peptides and Proteins
Myocardium
Homeostasis
Wounds and Injuries

Keywords

  • Cardiac myocytes
  • Cell-ECM communication
  • Extracellular matrix
  • Fibroblasts
  • Myocardial infarction
  • Proteomics

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

Cite this

Extracellular matrix and fibroblast communication following myocardial infarction. / Ma, Yonggang; Halade, Ganesh V.; Lindsey, Merry L.

In: Journal of Cardiovascular Translational Research, Vol. 5, No. 6, 01.12.2012, p. 848-857.

Research output: Contribution to journalArticle

@article{efbd842ebb82457a9a86a9f4982326e2,
title = "Extracellular matrix and fibroblast communication following myocardial infarction",
abstract = "The extracellular matrix (ECM) provides structural support by serving as a scaffold for cells, and as such the ECM maintains normal tissue homeostasis and mediates the repair response following injury. In response to myocardial infarction (MI), ECM expression is generally upregulated in the left ventricle (LV), which regulates LV remodeling by modulating scar formation. The ECM directly affects scar formation by regulating growth factor release and cell adhesion and indirectly affects scar formation by regulating the inflammatory, angiogenic, and fibroblast responses. This review summarizes the current literature on ECM expression patterns and fibroblast mechanisms in the myocardium, focusing on the ECM response to MI. In addition, we discuss future research areas that are needed to better understand the molecular mechanisms of ECM action, both in general and as a means to optimize infarct healing.",
keywords = "Cardiac myocytes, Cell-ECM communication, Extracellular matrix, Fibroblasts, Myocardial infarction, Proteomics",
author = "Yonggang Ma and Halade, {Ganesh V.} and Lindsey, {Merry L.}",
year = "2012",
month = "12",
day = "1",
doi = "10.1007/s12265-012-9398-z",
language = "English (US)",
volume = "5",
pages = "848--857",
journal = "Journal of Cardiovascular Translational Research",
issn = "1937-5387",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Extracellular matrix and fibroblast communication following myocardial infarction

AU - Ma, Yonggang

AU - Halade, Ganesh V.

AU - Lindsey, Merry L.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - The extracellular matrix (ECM) provides structural support by serving as a scaffold for cells, and as such the ECM maintains normal tissue homeostasis and mediates the repair response following injury. In response to myocardial infarction (MI), ECM expression is generally upregulated in the left ventricle (LV), which regulates LV remodeling by modulating scar formation. The ECM directly affects scar formation by regulating growth factor release and cell adhesion and indirectly affects scar formation by regulating the inflammatory, angiogenic, and fibroblast responses. This review summarizes the current literature on ECM expression patterns and fibroblast mechanisms in the myocardium, focusing on the ECM response to MI. In addition, we discuss future research areas that are needed to better understand the molecular mechanisms of ECM action, both in general and as a means to optimize infarct healing.

AB - The extracellular matrix (ECM) provides structural support by serving as a scaffold for cells, and as such the ECM maintains normal tissue homeostasis and mediates the repair response following injury. In response to myocardial infarction (MI), ECM expression is generally upregulated in the left ventricle (LV), which regulates LV remodeling by modulating scar formation. The ECM directly affects scar formation by regulating growth factor release and cell adhesion and indirectly affects scar formation by regulating the inflammatory, angiogenic, and fibroblast responses. This review summarizes the current literature on ECM expression patterns and fibroblast mechanisms in the myocardium, focusing on the ECM response to MI. In addition, we discuss future research areas that are needed to better understand the molecular mechanisms of ECM action, both in general and as a means to optimize infarct healing.

KW - Cardiac myocytes

KW - Cell-ECM communication

KW - Extracellular matrix

KW - Fibroblasts

KW - Myocardial infarction

KW - Proteomics

UR - http://www.scopus.com/inward/record.url?scp=84878193034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878193034&partnerID=8YFLogxK

U2 - 10.1007/s12265-012-9398-z

DO - 10.1007/s12265-012-9398-z

M3 - Article

C2 - 22926488

AN - SCOPUS:84878193034

VL - 5

SP - 848

EP - 857

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

SN - 1937-5387

IS - 6

ER -