Extracellular matrix

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

This chapter reviews the extracellular matrix constituents of the respiratory system. Until recently the extracellular matrix was thought of solely as a static structural support network. Now it is knows that the extracellular matrix is comprised by a large and varied group of dynamic macromolecules and their regulatory factors, which provides structural support and is a physical barrier. However, it also elicits cellular responses and its interactions are involved in development and organ formation. Disruption of normal extracellular matrix during disease processes can lead to an inflammatory response that exacerbates aberrant remodeling of the lung. The biomechanical properties of the lung are primarily determined by the extracellular matrix components that comprise the tissue. In the lung they can be largely categorized into four groups: the collagens, proteoglycans, elastic fibers, and non-collagenous proteins. The matrix of the normal lung imparts the strength and resilience for the continuous cycling of inspiration and expiration. For proper gas exchange, the components of the extracellular matrix are distributed in a fashion to reduce the boundary between erythrocytes and oxygen. When the exquisite balance of matrix glycoprotein is disturbed, the consequences on the lung are manifested by pathology. Heritable disorders of connective tissue (HDCT) are a series of disorders caused by mutations in structural or modifying components of the extracellular matrix. Since most of these gene products are expressed in multiple tissues, pleiotropic manifestations are observed in most HDCT. Alterations in connective tissue likely play key roles in the pathogenesis of both asthma and COPD.

Original languageEnglish (US)
Title of host publicationAsthma and COPD
PublisherElsevier Ltd
Pages265-274
Number of pages10
ISBN (Print)9780123740014
DOIs
StatePublished - Dec 1 2009

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Extracellular Matrix
Lung
Connective Tissue
Architectural Accessibility
Elastic Tissue
Proteoglycans
Respiratory System
Chronic Obstructive Pulmonary Disease
Glycoproteins
Collagen
Asthma
Erythrocytes
Gases
Pathology
Oxygen
Mutation
Genes
Proteins

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

Cite this

Godfrey, M. (2009). Extracellular matrix. In Asthma and COPD (pp. 265-274). Elsevier Ltd. https://doi.org/10.1016/B978-0-12-374001-4.00022-5

Extracellular matrix. / Godfrey, Maurice.

Asthma and COPD. Elsevier Ltd, 2009. p. 265-274.

Research output: Chapter in Book/Report/Conference proceedingChapter

Godfrey, M 2009, Extracellular matrix. in Asthma and COPD. Elsevier Ltd, pp. 265-274. https://doi.org/10.1016/B978-0-12-374001-4.00022-5
Godfrey M. Extracellular matrix. In Asthma and COPD. Elsevier Ltd. 2009. p. 265-274 https://doi.org/10.1016/B978-0-12-374001-4.00022-5
Godfrey, Maurice. / Extracellular matrix. Asthma and COPD. Elsevier Ltd, 2009. pp. 265-274
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