Expression of the RB gene under the control of MuLV-LTR suppresses tumorigenicity of WERI-Rb-27 retinoblastoma cells in immunodefective mice.

J. Sumegi, E. Uzvolgyi, G. Klein

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Retinoblastomas arise by the loss of the retinoblastoma (RB) gene. The isolation of the RB gene and its expression in RB protein defective tumor cells permits direct tests of the ability of the protein to act as a tumor suppressor. We demonstrate that a functional RB gene introduced into WERI-Rb-27 retinoblastoma cells by retrovirally mediated gene transfer can suppress their tumorigenicity in immunodefective mice.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalCell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
Volume1
Issue number5
StatePublished - May 1990

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Retinoblastoma Genes
Retinoblastoma
Retinoblastoma Protein
Neoplasms
Gene Expression
Genes
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

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abstract = "Retinoblastomas arise by the loss of the retinoblastoma (RB) gene. The isolation of the RB gene and its expression in RB protein defective tumor cells permits direct tests of the ability of the protein to act as a tumor suppressor. We demonstrate that a functional RB gene introduced into WERI-Rb-27 retinoblastoma cells by retrovirally mediated gene transfer can suppress their tumorigenicity in immunodefective mice.",
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