Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system

Hakim Hiel, Ana B. Elgoyhen, Dennis G. Drescher, Barbara J Morley

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The mRNA expression of the neuronal nicotinic acetylcholine receptor subunits was determined in adult rat vestibular end-organs and in Scarpa's ganglion (SCG) by in situ hybridization with [35S]riboprobes. Neurons in the SCG expressed the α4-7 and β2-3 mRNAs, but not α3 or β4 mRNAs. Not all SCG neurons expressed every mRNA found in SCG. The α6 and β2-3 riboprobes labeled all neurons, but α4, α5, and α7 mRNAs were selectively expressed in one or more subpopulations of SCG neurons. Vestibular sensory hair cells, in contrast, expressed only α9 mRNA.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalBrain Research
Volume738
Issue number2
DOIs
StatePublished - Nov 4 1996

Fingerprint

Vestibular Nerve
Nicotinic Receptors
Messenger RNA
Neurons
Vestibular Hair Cells
In Situ Hybridization

Keywords

  • Scarpa's ganglion
  • efferent
  • hair cell
  • hybridization, in situ
  • nicotinic acetylcholine receptor
  • vestibular

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system. / Hiel, Hakim; Elgoyhen, Ana B.; Drescher, Dennis G.; Morley, Barbara J.

In: Brain Research, Vol. 738, No. 2, 04.11.1996, p. 347-352.

Research output: Contribution to journalArticle

Hiel, Hakim ; Elgoyhen, Ana B. ; Drescher, Dennis G. ; Morley, Barbara J. / Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system. In: Brain Research. 1996 ; Vol. 738, No. 2. pp. 347-352.
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