Expression of mucin antigens (MUC1 and MUC16) as a prognostic factor for mucinous adenocarcinoma of the uterine cervix

Shinichi Togami, Mitsuharu Nomoto, Michiyo Higashi, Masamichi Goto, Suguru Yonezawa, Takahiro Tsuji, Surinder Kumar Batra, Tsutomu Douchi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aim: Only limited data are available regarding mucin antigen expression in adenocarcinoma of the uterine cervix. Methods: Fifty-two patients with mucinous adenocarcinoma of the endocervical type were enrolled for making clear implication of the mucin antigens. The expression of mucin antigens in hysterectomized specimens were determined immunohistochemically. Clinicopathological characteristics and prognosis included International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade, nodal and ovarian metastases, overall and disease-free survivals. The relationships of the expression of mucin antigens to various variables were investigated using uni- and multivariate analyses. Results: The majority of mucinous adenocarcinoma showed overexpression of MUC1 and MUC16. Overexpression of both MUC1 and MUC16 was associated with lower survival rates. Particularly, overexpression of MUC1 was associated with a lower disease-free survival rate and lymph node metastasis. However, absence of expression of MUC1 and/or MUC16 was associated with longer overall and disease-free survival. In cases classified as FIGO stage Ib (n = 35), after adjusting for patient age at diagnosis and stratifying by histological grade, MUC1 and/or MUC 16 overexpression was an independent prognostic factor for overall survival (hazard ratio [HR] = 6.16, 95% confidence interval [CI] = 1.01-118.5, P < 0.05). After stratifying by ovarian metastasis, MUC1 and/or MUC 16 overexpression was also an independent prognostic factor for disease-free survival (HR = 5.50, 95% CI = 0.82-87.4, P < 0.05). Conclusion: The expressions of MUC1 and/or MUC16 may be available as independent prognostic factors for the endocervical type of mucinous adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)588-597
Number of pages10
JournalJournal of Obstetrics and Gynaecology Research
Volume36
Issue number3
DOIs
StatePublished - Jun 2010

Fingerprint

Mucinous Adenocarcinoma
Mucins
Cervix Uteri
Disease-Free Survival
Antigens
Neoplasm Metastasis
Gynecology
Obstetrics
Survival Rate
Confidence Intervals
Adenocarcinoma
Multivariate Analysis
Lymph Nodes
Survival

Keywords

  • Disease-free survival
  • Hazard ratio
  • MUC1 expression
  • MUC16 expression
  • Mucinous adenocarcinoma of the endocervical type
  • Overall survival

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Expression of mucin antigens (MUC1 and MUC16) as a prognostic factor for mucinous adenocarcinoma of the uterine cervix. / Togami, Shinichi; Nomoto, Mitsuharu; Higashi, Michiyo; Goto, Masamichi; Yonezawa, Suguru; Tsuji, Takahiro; Batra, Surinder Kumar; Douchi, Tsutomu.

In: Journal of Obstetrics and Gynaecology Research, Vol. 36, No. 3, 06.2010, p. 588-597.

Research output: Contribution to journalArticle

Togami, Shinichi ; Nomoto, Mitsuharu ; Higashi, Michiyo ; Goto, Masamichi ; Yonezawa, Suguru ; Tsuji, Takahiro ; Batra, Surinder Kumar ; Douchi, Tsutomu. / Expression of mucin antigens (MUC1 and MUC16) as a prognostic factor for mucinous adenocarcinoma of the uterine cervix. In: Journal of Obstetrics and Gynaecology Research. 2010 ; Vol. 36, No. 3. pp. 588-597.
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abstract = "Aim: Only limited data are available regarding mucin antigen expression in adenocarcinoma of the uterine cervix. Methods: Fifty-two patients with mucinous adenocarcinoma of the endocervical type were enrolled for making clear implication of the mucin antigens. The expression of mucin antigens in hysterectomized specimens were determined immunohistochemically. Clinicopathological characteristics and prognosis included International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade, nodal and ovarian metastases, overall and disease-free survivals. The relationships of the expression of mucin antigens to various variables were investigated using uni- and multivariate analyses. Results: The majority of mucinous adenocarcinoma showed overexpression of MUC1 and MUC16. Overexpression of both MUC1 and MUC16 was associated with lower survival rates. Particularly, overexpression of MUC1 was associated with a lower disease-free survival rate and lymph node metastasis. However, absence of expression of MUC1 and/or MUC16 was associated with longer overall and disease-free survival. In cases classified as FIGO stage Ib (n = 35), after adjusting for patient age at diagnosis and stratifying by histological grade, MUC1 and/or MUC 16 overexpression was an independent prognostic factor for overall survival (hazard ratio [HR] = 6.16, 95{\%} confidence interval [CI] = 1.01-118.5, P < 0.05). After stratifying by ovarian metastasis, MUC1 and/or MUC 16 overexpression was also an independent prognostic factor for disease-free survival (HR = 5.50, 95{\%} CI = 0.82-87.4, P < 0.05). Conclusion: The expressions of MUC1 and/or MUC16 may be available as independent prognostic factors for the endocervical type of mucinous adenocarcinoma.",
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T1 - Expression of mucin antigens (MUC1 and MUC16) as a prognostic factor for mucinous adenocarcinoma of the uterine cervix

AU - Togami, Shinichi

AU - Nomoto, Mitsuharu

AU - Higashi, Michiyo

AU - Goto, Masamichi

AU - Yonezawa, Suguru

AU - Tsuji, Takahiro

AU - Batra, Surinder Kumar

AU - Douchi, Tsutomu

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N2 - Aim: Only limited data are available regarding mucin antigen expression in adenocarcinoma of the uterine cervix. Methods: Fifty-two patients with mucinous adenocarcinoma of the endocervical type were enrolled for making clear implication of the mucin antigens. The expression of mucin antigens in hysterectomized specimens were determined immunohistochemically. Clinicopathological characteristics and prognosis included International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade, nodal and ovarian metastases, overall and disease-free survivals. The relationships of the expression of mucin antigens to various variables were investigated using uni- and multivariate analyses. Results: The majority of mucinous adenocarcinoma showed overexpression of MUC1 and MUC16. Overexpression of both MUC1 and MUC16 was associated with lower survival rates. Particularly, overexpression of MUC1 was associated with a lower disease-free survival rate and lymph node metastasis. However, absence of expression of MUC1 and/or MUC16 was associated with longer overall and disease-free survival. In cases classified as FIGO stage Ib (n = 35), after adjusting for patient age at diagnosis and stratifying by histological grade, MUC1 and/or MUC 16 overexpression was an independent prognostic factor for overall survival (hazard ratio [HR] = 6.16, 95% confidence interval [CI] = 1.01-118.5, P < 0.05). After stratifying by ovarian metastasis, MUC1 and/or MUC 16 overexpression was also an independent prognostic factor for disease-free survival (HR = 5.50, 95% CI = 0.82-87.4, P < 0.05). Conclusion: The expressions of MUC1 and/or MUC16 may be available as independent prognostic factors for the endocervical type of mucinous adenocarcinoma.

AB - Aim: Only limited data are available regarding mucin antigen expression in adenocarcinoma of the uterine cervix. Methods: Fifty-two patients with mucinous adenocarcinoma of the endocervical type were enrolled for making clear implication of the mucin antigens. The expression of mucin antigens in hysterectomized specimens were determined immunohistochemically. Clinicopathological characteristics and prognosis included International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade, nodal and ovarian metastases, overall and disease-free survivals. The relationships of the expression of mucin antigens to various variables were investigated using uni- and multivariate analyses. Results: The majority of mucinous adenocarcinoma showed overexpression of MUC1 and MUC16. Overexpression of both MUC1 and MUC16 was associated with lower survival rates. Particularly, overexpression of MUC1 was associated with a lower disease-free survival rate and lymph node metastasis. However, absence of expression of MUC1 and/or MUC16 was associated with longer overall and disease-free survival. In cases classified as FIGO stage Ib (n = 35), after adjusting for patient age at diagnosis and stratifying by histological grade, MUC1 and/or MUC 16 overexpression was an independent prognostic factor for overall survival (hazard ratio [HR] = 6.16, 95% confidence interval [CI] = 1.01-118.5, P < 0.05). After stratifying by ovarian metastasis, MUC1 and/or MUC 16 overexpression was also an independent prognostic factor for disease-free survival (HR = 5.50, 95% CI = 0.82-87.4, P < 0.05). Conclusion: The expressions of MUC1 and/or MUC16 may be available as independent prognostic factors for the endocervical type of mucinous adenocarcinoma.

KW - Disease-free survival

KW - Hazard ratio

KW - MUC1 expression

KW - MUC16 expression

KW - Mucinous adenocarcinoma of the endocervical type

KW - Overall survival

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