Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms

Claudia Figueroa-Romero, Junguk Hur, J. Simon Lunn, Ximena Paez-Colasante, Diane E. Bender, Raymond Yung, Stacey A. Sakowski, Eva L. Feldman

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Amyotrophic lateral sclerosis is a late-onset and terminal neurodegenerative disease. The majority of cases are sporadic with unknown causes and only a small number of cases are genetically linked. Recent evidence suggests that post-transcriptional regulation and epigenetic mechanisms, such as microRNAs, underlie the onset and progression of neurodegenerative disorders; therefore, altered microRNA expression may result in the dysregulation of key genes and biological pathways that contribute to the development of sporadic amyotrophic lateral sclerosis. Using systems biology analyses on postmortem human spinal cord tissue, we identified dysregulated mature microRNAs and their potential targets previously implicated in functional process and pathways associated with the pathogenesis of ALS. Furthermore, we report a global reduction of mature microRNAs, alterations in microRNA processing, and support for a role of the nucleotide binding protein, TAR DNA binding protein 43, in regulating sporadic amyotrophic lateral sclerosis-associated microRNAs, thereby offering a potential underlying mechanism for sporadic amyotrophic lateral sclerosis.

Original languageEnglish (US)
Pages (from-to)34-45
Number of pages12
JournalMolecular and Cellular Neuroscience
Volume71
DOIs
StatePublished - Mar 1 2016

Fingerprint

Amyotrophic Lateral Sclerosis
MicroRNAs
Spinal Cord
Neurodegenerative Diseases
Systems Biology
DNA-Binding Proteins
Epigenomics
Carrier Proteins
Nucleotides
Genes
Amyotrophic lateral sclerosis 1

Keywords

  • Amyotrophic lateral sclerosis
  • Epigenetics
  • MicroRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms. / Figueroa-Romero, Claudia; Hur, Junguk; Lunn, J. Simon; Paez-Colasante, Ximena; Bender, Diane E.; Yung, Raymond; Sakowski, Stacey A.; Feldman, Eva L.

In: Molecular and Cellular Neuroscience, Vol. 71, 01.03.2016, p. 34-45.

Research output: Contribution to journalArticle

Figueroa-Romero, Claudia ; Hur, Junguk ; Lunn, J. Simon ; Paez-Colasante, Ximena ; Bender, Diane E. ; Yung, Raymond ; Sakowski, Stacey A. ; Feldman, Eva L. / Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms. In: Molecular and Cellular Neuroscience. 2016 ; Vol. 71. pp. 34-45.
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