Expression of E-cadherin, P-cadherin and N-cadherin in oral squamous cell carcinoma: Correlation with the clinicopathologic features and patient outcome

Sung Woon PYO, Mitsuyoshi HASHIMOTO, Young Sill KIM, Chang Hyen KIM, Sang Hwa LEE, Keith R Johnson, Margaret J. WHEELOCK, Je Uk PARK

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Purpose: Alteration of cadherin expression is associated with the loss of cellular differentiation, the acquisition of an invasive phenotype and a poor prognosis in many types of cancer. This study aimed to evaluate the immunoreactivity of E-, P- and N-cadherins (cad) in oral squamous cell carcinoma and to correlate their expression with clinicopathological features and clinical outcome. The interaction between the cadherins was also investigated. Methods: A total of 71 tissue samples were examined by immunohistochemical methods on paraffin sections using specific antibodies. Results: In the primary lesions and lymph node metastases, the immunoreactivity of E-cad was reduced and P-cad was over-expressed, but the expression of N-cad was negative (p<0.001, 0.01 and 0.05, respectively). The reduced primary E-cad expression was related to the invasion pattern and lymph node metastasis (p=0.046 and 0.037, respectively). However, the expression of cadherins did not appear to differ significantly in relation to the histological grade, invasion, tumour size, stage of oral SCC or tumour recurrence. A much greater reduction in the expression of E-cad was found in the positive N-cadherin group (p=0.008). Nonetheless, cadherin expression was not significantly associated with failure-free survival or overall survival in this experiment subset. Conclusion: The reduced E-cad expression and the aberrant N-cad expression are closely associated with each other in oral cancer cases, and this suggests that cadherin switching from E. cad to N. cad may play a critical role in cancer development and metastasis.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalJournal of Cranio-Maxillofacial Surgery
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2007

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Cadherins
Squamous Cell Carcinoma
Neoplasm Metastasis
Neoplasms
Oral Stage
Lymph Nodes
Survival
Mouth Neoplasms
Paraffin

Keywords

  • E-cadherin, P-cadherin, N-cadherin, oral squamous cell carcinoma, survival, cadherin switching, metastasis

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

Expression of E-cadherin, P-cadherin and N-cadherin in oral squamous cell carcinoma : Correlation with the clinicopathologic features and patient outcome. / PYO, Sung Woon; HASHIMOTO, Mitsuyoshi; KIM, Young Sill; KIM, Chang Hyen; LEE, Sang Hwa; Johnson, Keith R; WHEELOCK, Margaret J.; PARK, Je Uk.

In: Journal of Cranio-Maxillofacial Surgery, Vol. 35, No. 1, 01.01.2007, p. 1-9.

Research output: Contribution to journalArticle

PYO, Sung Woon ; HASHIMOTO, Mitsuyoshi ; KIM, Young Sill ; KIM, Chang Hyen ; LEE, Sang Hwa ; Johnson, Keith R ; WHEELOCK, Margaret J. ; PARK, Je Uk. / Expression of E-cadherin, P-cadherin and N-cadherin in oral squamous cell carcinoma : Correlation with the clinicopathologic features and patient outcome. In: Journal of Cranio-Maxillofacial Surgery. 2007 ; Vol. 35, No. 1. pp. 1-9.
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abstract = "Purpose: Alteration of cadherin expression is associated with the loss of cellular differentiation, the acquisition of an invasive phenotype and a poor prognosis in many types of cancer. This study aimed to evaluate the immunoreactivity of E-, P- and N-cadherins (cad) in oral squamous cell carcinoma and to correlate their expression with clinicopathological features and clinical outcome. The interaction between the cadherins was also investigated. Methods: A total of 71 tissue samples were examined by immunohistochemical methods on paraffin sections using specific antibodies. Results: In the primary lesions and lymph node metastases, the immunoreactivity of E-cad was reduced and P-cad was over-expressed, but the expression of N-cad was negative (p<0.001, 0.01 and 0.05, respectively). The reduced primary E-cad expression was related to the invasion pattern and lymph node metastasis (p=0.046 and 0.037, respectively). However, the expression of cadherins did not appear to differ significantly in relation to the histological grade, invasion, tumour size, stage of oral SCC or tumour recurrence. A much greater reduction in the expression of E-cad was found in the positive N-cadherin group (p=0.008). Nonetheless, cadherin expression was not significantly associated with failure-free survival or overall survival in this experiment subset. Conclusion: The reduced E-cad expression and the aberrant N-cad expression are closely associated with each other in oral cancer cases, and this suggests that cadherin switching from E. cad to N. cad may play a critical role in cancer development and metastasis.",
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T1 - Expression of E-cadherin, P-cadherin and N-cadherin in oral squamous cell carcinoma

T2 - Correlation with the clinicopathologic features and patient outcome

AU - PYO, Sung Woon

AU - HASHIMOTO, Mitsuyoshi

AU - KIM, Young Sill

AU - KIM, Chang Hyen

AU - LEE, Sang Hwa

AU - Johnson, Keith R

AU - WHEELOCK, Margaret J.

AU - PARK, Je Uk

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Purpose: Alteration of cadherin expression is associated with the loss of cellular differentiation, the acquisition of an invasive phenotype and a poor prognosis in many types of cancer. This study aimed to evaluate the immunoreactivity of E-, P- and N-cadherins (cad) in oral squamous cell carcinoma and to correlate their expression with clinicopathological features and clinical outcome. The interaction between the cadherins was also investigated. Methods: A total of 71 tissue samples were examined by immunohistochemical methods on paraffin sections using specific antibodies. Results: In the primary lesions and lymph node metastases, the immunoreactivity of E-cad was reduced and P-cad was over-expressed, but the expression of N-cad was negative (p<0.001, 0.01 and 0.05, respectively). The reduced primary E-cad expression was related to the invasion pattern and lymph node metastasis (p=0.046 and 0.037, respectively). However, the expression of cadherins did not appear to differ significantly in relation to the histological grade, invasion, tumour size, stage of oral SCC or tumour recurrence. A much greater reduction in the expression of E-cad was found in the positive N-cadherin group (p=0.008). Nonetheless, cadherin expression was not significantly associated with failure-free survival or overall survival in this experiment subset. Conclusion: The reduced E-cad expression and the aberrant N-cad expression are closely associated with each other in oral cancer cases, and this suggests that cadherin switching from E. cad to N. cad may play a critical role in cancer development and metastasis.

AB - Purpose: Alteration of cadherin expression is associated with the loss of cellular differentiation, the acquisition of an invasive phenotype and a poor prognosis in many types of cancer. This study aimed to evaluate the immunoreactivity of E-, P- and N-cadherins (cad) in oral squamous cell carcinoma and to correlate their expression with clinicopathological features and clinical outcome. The interaction between the cadherins was also investigated. Methods: A total of 71 tissue samples were examined by immunohistochemical methods on paraffin sections using specific antibodies. Results: In the primary lesions and lymph node metastases, the immunoreactivity of E-cad was reduced and P-cad was over-expressed, but the expression of N-cad was negative (p<0.001, 0.01 and 0.05, respectively). The reduced primary E-cad expression was related to the invasion pattern and lymph node metastasis (p=0.046 and 0.037, respectively). However, the expression of cadherins did not appear to differ significantly in relation to the histological grade, invasion, tumour size, stage of oral SCC or tumour recurrence. A much greater reduction in the expression of E-cad was found in the positive N-cadherin group (p=0.008). Nonetheless, cadherin expression was not significantly associated with failure-free survival or overall survival in this experiment subset. Conclusion: The reduced E-cad expression and the aberrant N-cad expression are closely associated with each other in oral cancer cases, and this suggests that cadherin switching from E. cad to N. cad may play a critical role in cancer development and metastasis.

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