Exploiting self-assembly for ligand-scaffold optimization: Substrate-tailored ligands for efficient catalytic asymmetric hydroboration

Shin A. Moteki, James M. Takacs

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

(Chemical Equation Presented) Mix and match: A self-assembled ligand library (SAL XY) affords a wide range of R/S ratios in Rh-catalyzed asymmetric hydroboration (see scheme; nbd = 2,5-norbornadiene, R* is a chiral substituent). Ligand-scaffold optimization reveals "substrate- tailored" ligands that afford high regio- and enantioselectivity for a variety of ortho-substituted styrene derivatives.

Original languageEnglish (US)
Pages (from-to)894-897
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number5
DOIs
Publication statusPublished - Feb 1 2008

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Keywords

  • Asymmetric synthesis
  • Combinatorial chemistry
  • Hydroboration
  • Self-assembly
  • Stereoselective catalysis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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