Experimental evidence for adaptation to species-specific gut microbiota in house mice

Andrew H. Moeller, João C. Gomes-Neto, Sara Mantz, Hatem Kittana, Rafael R.Segura Munoz, Robert J. Schmaltz, Amanda E. Ramer-Tait, Michael W. Nachman

Research output: Contribution to journalArticle

Abstract

The gut microbial communities of mammals have codiversified with host species, and changes in the gut microbiota can have profound effects on host fitness. Therefore, the gut microbiota may drive adaptation in mammalian species, but this possibility is underexplored. Here, we show that the gut microbiota has codiversified with mice in the genus Mus over the past ~6 million years, and we present experimental evidence that the gut microbiota has driven adaptive evolution of the house mouse, Mus musculus domesticus. Phylogenetic analyses of metagenomeassembled bacterial genomic sequences revealed that gut bacterial lineages have been retained within and diversified alongside Mus species over evolutionary time. Transplantation of gut microbiotas from various Mus species into germfree M. m. domesticus showed that foreign gut microbiotas slowed growth rate and upregulated macrophage inflammatory protein in hosts. These results suggest adaptation by M. m. domesticus to its gut microbiota since it diverged from other Mus species.

Original languageEnglish (US)
Article numbere00387-19
JournalmSphere
Volume4
Issue number4
DOIs
StatePublished - Jan 1 2019

Fingerprint

Macrophage Inflammatory Proteins
Gastrointestinal Microbiome
Mammals
Transplantation
Growth

Keywords

  • Evolutionary biology
  • Metagenomics
  • Microbial ecology

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

Moeller, A. H., Gomes-Neto, J. C., Mantz, S., Kittana, H., Munoz, R. R. S., Schmaltz, R. J., ... Nachman, M. W. (2019). Experimental evidence for adaptation to species-specific gut microbiota in house mice. mSphere, 4(4), [e00387-19]. https://doi.org/10.1128/mSphere.00387-19

Experimental evidence for adaptation to species-specific gut microbiota in house mice. / Moeller, Andrew H.; Gomes-Neto, João C.; Mantz, Sara; Kittana, Hatem; Munoz, Rafael R.Segura; Schmaltz, Robert J.; Ramer-Tait, Amanda E.; Nachman, Michael W.

In: mSphere, Vol. 4, No. 4, e00387-19, 01.01.2019.

Research output: Contribution to journalArticle

Moeller, AH, Gomes-Neto, JC, Mantz, S, Kittana, H, Munoz, RRS, Schmaltz, RJ, Ramer-Tait, AE & Nachman, MW 2019, 'Experimental evidence for adaptation to species-specific gut microbiota in house mice', mSphere, vol. 4, no. 4, e00387-19. https://doi.org/10.1128/mSphere.00387-19
Moeller AH, Gomes-Neto JC, Mantz S, Kittana H, Munoz RRS, Schmaltz RJ et al. Experimental evidence for adaptation to species-specific gut microbiota in house mice. mSphere. 2019 Jan 1;4(4). e00387-19. https://doi.org/10.1128/mSphere.00387-19
Moeller, Andrew H. ; Gomes-Neto, João C. ; Mantz, Sara ; Kittana, Hatem ; Munoz, Rafael R.Segura ; Schmaltz, Robert J. ; Ramer-Tait, Amanda E. ; Nachman, Michael W. / Experimental evidence for adaptation to species-specific gut microbiota in house mice. In: mSphere. 2019 ; Vol. 4, No. 4.
@article{9f58669217f64c23ab1c87180d171862,
title = "Experimental evidence for adaptation to species-specific gut microbiota in house mice",
abstract = "The gut microbial communities of mammals have codiversified with host species, and changes in the gut microbiota can have profound effects on host fitness. Therefore, the gut microbiota may drive adaptation in mammalian species, but this possibility is underexplored. Here, we show that the gut microbiota has codiversified with mice in the genus Mus over the past ~6 million years, and we present experimental evidence that the gut microbiota has driven adaptive evolution of the house mouse, Mus musculus domesticus. Phylogenetic analyses of metagenomeassembled bacterial genomic sequences revealed that gut bacterial lineages have been retained within and diversified alongside Mus species over evolutionary time. Transplantation of gut microbiotas from various Mus species into germfree M. m. domesticus showed that foreign gut microbiotas slowed growth rate and upregulated macrophage inflammatory protein in hosts. These results suggest adaptation by M. m. domesticus to its gut microbiota since it diverged from other Mus species.",
keywords = "Evolutionary biology, Metagenomics, Microbial ecology",
author = "Moeller, {Andrew H.} and Gomes-Neto, {Jo{\~a}o C.} and Sara Mantz and Hatem Kittana and Munoz, {Rafael R.Segura} and Schmaltz, {Robert J.} and Ramer-Tait, {Amanda E.} and Nachman, {Michael W.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1128/mSphere.00387-19",
language = "English (US)",
volume = "4",
journal = "mSphere",
issn = "2379-5042",
publisher = "American Society for Microbiology",
number = "4",

}

TY - JOUR

T1 - Experimental evidence for adaptation to species-specific gut microbiota in house mice

AU - Moeller, Andrew H.

AU - Gomes-Neto, João C.

AU - Mantz, Sara

AU - Kittana, Hatem

AU - Munoz, Rafael R.Segura

AU - Schmaltz, Robert J.

AU - Ramer-Tait, Amanda E.

AU - Nachman, Michael W.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The gut microbial communities of mammals have codiversified with host species, and changes in the gut microbiota can have profound effects on host fitness. Therefore, the gut microbiota may drive adaptation in mammalian species, but this possibility is underexplored. Here, we show that the gut microbiota has codiversified with mice in the genus Mus over the past ~6 million years, and we present experimental evidence that the gut microbiota has driven adaptive evolution of the house mouse, Mus musculus domesticus. Phylogenetic analyses of metagenomeassembled bacterial genomic sequences revealed that gut bacterial lineages have been retained within and diversified alongside Mus species over evolutionary time. Transplantation of gut microbiotas from various Mus species into germfree M. m. domesticus showed that foreign gut microbiotas slowed growth rate and upregulated macrophage inflammatory protein in hosts. These results suggest adaptation by M. m. domesticus to its gut microbiota since it diverged from other Mus species.

AB - The gut microbial communities of mammals have codiversified with host species, and changes in the gut microbiota can have profound effects on host fitness. Therefore, the gut microbiota may drive adaptation in mammalian species, but this possibility is underexplored. Here, we show that the gut microbiota has codiversified with mice in the genus Mus over the past ~6 million years, and we present experimental evidence that the gut microbiota has driven adaptive evolution of the house mouse, Mus musculus domesticus. Phylogenetic analyses of metagenomeassembled bacterial genomic sequences revealed that gut bacterial lineages have been retained within and diversified alongside Mus species over evolutionary time. Transplantation of gut microbiotas from various Mus species into germfree M. m. domesticus showed that foreign gut microbiotas slowed growth rate and upregulated macrophage inflammatory protein in hosts. These results suggest adaptation by M. m. domesticus to its gut microbiota since it diverged from other Mus species.

KW - Evolutionary biology

KW - Metagenomics

KW - Microbial ecology

UR - http://www.scopus.com/inward/record.url?scp=85069569305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069569305&partnerID=8YFLogxK

U2 - 10.1128/mSphere.00387-19

DO - 10.1128/mSphere.00387-19

M3 - Article

C2 - 31292233

AN - SCOPUS:85069569305

VL - 4

JO - mSphere

JF - mSphere

SN - 2379-5042

IS - 4

M1 - e00387-19

ER -