Expanding Therapeutic Options for Older Adults: Case-Based Updates in Breast and Lung Cancer

Allison Magnuson, Rawad Elias, Thuy Koll

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Oncology care has become increasingly complex, with a dramatic increase in the number of available therapy options. Many newly developed medications have novel mechanisms of action and include targeted therapies and immunotherapy options. These agents typically have unique side effects that differ from more traditional cytotoxic chemotherapy regimens. Older adults represent the majority of patients with cancer and it is important for geriatricians and primary care providers for older adults to have a general understanding of newer agents and novel therapies, in order to aid in decision-making and supportive care strategies during oncology treatment. This review provides a case-based approach to discussing emerging therapeutic treatment options, including targeted therapies and immune-based therapies, in two common malignancies affecting older adults. Incorporation of available evidence of specific novel therapies in older adult populations is discussed. J Am Geriatr Soc 67:1012–1019, 2019.

Original languageEnglish (US)
Pages (from-to)1012-1019
Number of pages8
JournalJournal of the American Geriatrics Society
Volume67
Issue number5
DOIs
StatePublished - May 2019

Fingerprint

Lung Neoplasms
Breast Neoplasms
Therapeutics
Immunotherapy
Neoplasms
Primary Health Care
Decision Making
Drug Therapy
Population

Keywords

  • cancer therapy
  • case-based review
  • geriatric oncology

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Expanding Therapeutic Options for Older Adults : Case-Based Updates in Breast and Lung Cancer. / Magnuson, Allison; Elias, Rawad; Koll, Thuy.

In: Journal of the American Geriatrics Society, Vol. 67, No. 5, 05.2019, p. 1012-1019.

Research output: Contribution to journalReview article

@article{ec2ad48a80a943939e7b7c3917d80132,
title = "Expanding Therapeutic Options for Older Adults: Case-Based Updates in Breast and Lung Cancer",
abstract = "Oncology care has become increasingly complex, with a dramatic increase in the number of available therapy options. Many newly developed medications have novel mechanisms of action and include targeted therapies and immunotherapy options. These agents typically have unique side effects that differ from more traditional cytotoxic chemotherapy regimens. Older adults represent the majority of patients with cancer and it is important for geriatricians and primary care providers for older adults to have a general understanding of newer agents and novel therapies, in order to aid in decision-making and supportive care strategies during oncology treatment. This review provides a case-based approach to discussing emerging therapeutic treatment options, including targeted therapies and immune-based therapies, in two common malignancies affecting older adults. Incorporation of available evidence of specific novel therapies in older adult populations is discussed. J Am Geriatr Soc 67:1012–1019, 2019.",
keywords = "cancer therapy, case-based review, geriatric oncology",
author = "Allison Magnuson and Rawad Elias and Thuy Koll",
year = "2019",
month = "5",
doi = "10.1111/jgs.15943",
language = "English (US)",
volume = "67",
pages = "1012--1019",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Expanding Therapeutic Options for Older Adults

T2 - Case-Based Updates in Breast and Lung Cancer

AU - Magnuson, Allison

AU - Elias, Rawad

AU - Koll, Thuy

PY - 2019/5

Y1 - 2019/5

N2 - Oncology care has become increasingly complex, with a dramatic increase in the number of available therapy options. Many newly developed medications have novel mechanisms of action and include targeted therapies and immunotherapy options. These agents typically have unique side effects that differ from more traditional cytotoxic chemotherapy regimens. Older adults represent the majority of patients with cancer and it is important for geriatricians and primary care providers for older adults to have a general understanding of newer agents and novel therapies, in order to aid in decision-making and supportive care strategies during oncology treatment. This review provides a case-based approach to discussing emerging therapeutic treatment options, including targeted therapies and immune-based therapies, in two common malignancies affecting older adults. Incorporation of available evidence of specific novel therapies in older adult populations is discussed. J Am Geriatr Soc 67:1012–1019, 2019.

AB - Oncology care has become increasingly complex, with a dramatic increase in the number of available therapy options. Many newly developed medications have novel mechanisms of action and include targeted therapies and immunotherapy options. These agents typically have unique side effects that differ from more traditional cytotoxic chemotherapy regimens. Older adults represent the majority of patients with cancer and it is important for geriatricians and primary care providers for older adults to have a general understanding of newer agents and novel therapies, in order to aid in decision-making and supportive care strategies during oncology treatment. This review provides a case-based approach to discussing emerging therapeutic treatment options, including targeted therapies and immune-based therapies, in two common malignancies affecting older adults. Incorporation of available evidence of specific novel therapies in older adult populations is discussed. J Am Geriatr Soc 67:1012–1019, 2019.

KW - cancer therapy

KW - case-based review

KW - geriatric oncology

UR - http://www.scopus.com/inward/record.url?scp=85065104029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065104029&partnerID=8YFLogxK

U2 - 10.1111/jgs.15943

DO - 10.1111/jgs.15943

M3 - Review article

C2 - 31034592

AN - SCOPUS:85065104029

VL - 67

SP - 1012

EP - 1019

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 5

ER -