Exosomal miRNAs

Biological properties and therapeutic potential

Guoku Hu, Kristen M. Drescher, Xian Ming Chen

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

MicroRNAs (miRNAs), small non-coding regulatory RNAs that regulate gene expression at the post-transcriptional level, are master regulators of a wide array of cellular processes. Altered miRNA expression could be a determinant of disease development and/or progression and manipulation of miRNA expression represents a potential avenue of therapy. Exosomes are cell-derived extracellular vesicles that promote cell-cell communication and immunoregulatory functions. These "bioactive vesicles" shuttle various molecules, including miRNAs, to recipient cells. Inappropriate release of miRNAs from exosomes may cause significant alterations in biological pathways that affect disease development, supporting the concept that miRNA-containing exosomes could serve as targeted therapies for particular diseases. This review briefly summarizes recent advances in the biology, function, and therapeutic potential of exosomal miRNAs.

Original languageEnglish (US)
Article numberArticle 56
JournalFrontiers in Genetics
Volume3
Issue numberAPR
DOIs
StatePublished - Dec 1 2012

Fingerprint

MicroRNAs
Exosomes
Therapeutics
Small Untranslated RNA
Cell Communication
Gene Expression

Keywords

  • Cancer
  • Exosomes
  • MicroRNAs
  • Post-transcriptional regulation
  • Therapy

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Genetics(clinical)

Cite this

Exosomal miRNAs : Biological properties and therapeutic potential. / Hu, Guoku; Drescher, Kristen M.; Chen, Xian Ming.

In: Frontiers in Genetics, Vol. 3, No. APR, Article 56, 01.12.2012.

Research output: Contribution to journalArticle

Hu, Guoku ; Drescher, Kristen M. ; Chen, Xian Ming. / Exosomal miRNAs : Biological properties and therapeutic potential. In: Frontiers in Genetics. 2012 ; Vol. 3, No. APR.
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