Exogenous Progestogen and Estrogen Implicated in Birth Defects

James J. Nora, Audrey H. Nora, Janet Blu, Joy Ingram, Agnes Fountain, Marilyn Peterson, Randall H. Lortscher, William J. Kimberling

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Abstract

A five-year study of the possible teratogenicity of exogenous female sex hormones included three case-control studies and one cohort study. The first case-control study disclosed an estimated relative risk of 8.41 and a highly significant difference in maternal hormonal exposure (P<.001) between controls and infants with three major anomalies of the VACTERL group (V, vertebral; A, anal; C, cardiac; T, tracheal; E, esophageal; R, renal; and L, limb). Relative risk (RR) estimates of 5.58 (P=.017) and 3.35 (P<.001) were found in two case-control studies involving maternal hormonal exposure and patients with congenital heart lesions without other malformations. A controlled, single-blind prospective study disclosed an excess of patients with major malformations (RR=2.75), congenital heart anomalies (RR=6), and neurological and neural tube disorders preponderant in the presence of a precipitously declining exposure rate during a three-year period in our referral area.

Original languageEnglish (US)
Pages (from-to)837-843
Number of pages7
JournalJAMA: The Journal of the American Medical Association
Volume240
Issue number9
DOIs
StatePublished - Sep 1 1978

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Progestins
Estrogens
Case-Control Studies
Maternal Exposure
Single-Blind Method
Neural Tube
Gonadal Steroid Hormones
Cohort Studies
Referral and Consultation
Extremities
Prospective Studies
Kidney

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nora, J. J., Nora, A. H., Blu, J., Ingram, J., Fountain, A., Peterson, M., ... Kimberling, W. J. (1978). Exogenous Progestogen and Estrogen Implicated in Birth Defects. JAMA: The Journal of the American Medical Association, 240(9), 837-843. https://doi.org/10.1001/jama.1978.03290090031012

Exogenous Progestogen and Estrogen Implicated in Birth Defects. / Nora, James J.; Nora, Audrey H.; Blu, Janet; Ingram, Joy; Fountain, Agnes; Peterson, Marilyn; Lortscher, Randall H.; Kimberling, William J.

In: JAMA: The Journal of the American Medical Association, Vol. 240, No. 9, 01.09.1978, p. 837-843.

Research output: Contribution to journalArticle

Nora, JJ, Nora, AH, Blu, J, Ingram, J, Fountain, A, Peterson, M, Lortscher, RH & Kimberling, WJ 1978, 'Exogenous Progestogen and Estrogen Implicated in Birth Defects', JAMA: The Journal of the American Medical Association, vol. 240, no. 9, pp. 837-843. https://doi.org/10.1001/jama.1978.03290090031012
Nora, James J. ; Nora, Audrey H. ; Blu, Janet ; Ingram, Joy ; Fountain, Agnes ; Peterson, Marilyn ; Lortscher, Randall H. ; Kimberling, William J. / Exogenous Progestogen and Estrogen Implicated in Birth Defects. In: JAMA: The Journal of the American Medical Association. 1978 ; Vol. 240, No. 9. pp. 837-843.
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