Exogenous porcine viruses

Prem S Paul, P. Halbur, B. Janke, H. Joo, P. Nawagitgul, J. Singh, S. Sorden

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Porcine organs, cells and tissues provide a viable source of transplants in humans, though there is some concern of public health risk from adaptation of swine infectious agents in humans. Limited information is available on the public health risk of many exogenous swine viruses, and reliable and rapid diagnostic tests are available for only a few of these. The ability of several porcine viruses to cause transplacental fetal infection (parvoviruses, circoviruses, and arteriviruses), emergence or recognition of several new porcine viruses during the last two decades (porcine circovirus, arterivirus, paramyxoviruses, herpesviruses, and porcine respiratory coronavirus) and the immunosuppressed state of the transplant recipients increases the xenozoonoses risk of humans to porcine viruses through transplantation. Much of this risk can be eliminated with vigilance and sustained monitoring along with a better understanding of pathogenesis and development of better diagnostic tests. In this review we present information on selected exogenous viruses, highlighting their characteristics, pathogenesis of viral infections in swine, methods for their detection, and the potential xenozoonoses risk they present. Emphasis has been given in this review to swine influenza virus, paramyxovirus (Nipah virus, Menagle virus, LaPiedad paramyxovirus, porcine paramyxovirus), arterivirus (porcine reproductive and respiratory syndrome virus) and circovirus as either they represent new swine viruses or present the greatest risk. We have also presented information on porcine parvovirus, Japanese encephalitis virus, encephalomyocarditis virus, herpesviruses (pseudorabies virus, porcine lymphotropic herpesvirus, porcine cytomegalovirus), coronaviruses (TGEV, PRCV, HEV, PEDV) and adenovirus. The potential of swine viruses to infect humans needs to be assessed in vitro and in vivo and rapid and more reliable diagnostic methods need to be developed to assure safe supply of porcine tissues and cells for xenotransplantation.

Original languageEnglish (US)
Pages (from-to)125-183
Number of pages59
JournalCurrent topics in microbiology and immunology
Volume278
StatePublished - Aug 15 2003

Fingerprint

Swine
Viruses
Herpesviridae
Arterivirus
Circovirus
Arterivirus Infections
Routine Diagnostic Tests
Porcine Respiratory Coronavirus
Japanese Encephalitis Virus
Circoviridae Infections
Nipah Virus
Porcine Parvovirus
Public Health
Encephalomyocarditis virus
Porcine respiratory and reproductive syndrome virus
Parvoviridae Infections
Suid Herpesvirus 1
Heterologous Transplantation
Coronavirus
Virus Diseases

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Paul, P. S., Halbur, P., Janke, B., Joo, H., Nawagitgul, P., Singh, J., & Sorden, S. (2003). Exogenous porcine viruses. Current topics in microbiology and immunology, 278, 125-183.

Exogenous porcine viruses. / Paul, Prem S; Halbur, P.; Janke, B.; Joo, H.; Nawagitgul, P.; Singh, J.; Sorden, S.

In: Current topics in microbiology and immunology, Vol. 278, 15.08.2003, p. 125-183.

Research output: Contribution to journalReview article

Paul, PS, Halbur, P, Janke, B, Joo, H, Nawagitgul, P, Singh, J & Sorden, S 2003, 'Exogenous porcine viruses', Current topics in microbiology and immunology, vol. 278, pp. 125-183.
Paul PS, Halbur P, Janke B, Joo H, Nawagitgul P, Singh J et al. Exogenous porcine viruses. Current topics in microbiology and immunology. 2003 Aug 15;278:125-183.
Paul, Prem S ; Halbur, P. ; Janke, B. ; Joo, H. ; Nawagitgul, P. ; Singh, J. ; Sorden, S. / Exogenous porcine viruses. In: Current topics in microbiology and immunology. 2003 ; Vol. 278. pp. 125-183.
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