Exhaled Nitric Oxide Levels Among Adults With Excessive Alcohol Consumption

Majid Afshar, Jill A Poole, Guichan Cao, Ramon Durazo, Richard C. Cooper, Elizabeth J. Kovacs, Joseph Harold Sisson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background More than one-quarter of the US population qualify as excessive alcohol consumers. Alcohol use impacts several lung diseases, and heavy consumption has been associated with poor clinical outcomes. The fractional excretion of exhaled nitric oxide (FENO) has clinical implications in multiple airways diseases. We hypothesized that excessive alcohol intake is associated with lower FENO levels. Methods To test this hypothesis, we examined a sample consisting of 12,059 participants, aged 21 to 79 years, interviewed between 2007 and 2012 from the National Health and Examination Survey. Two valid FENO measurements that were reproducible were recorded. Alcohol questionnaire data were used to define the following alcohol groups: never drinkers, nonexcessive drinkers, excessive drinkers, and former excessive drinkers. The natural logarithm of FENO values [ln(FENO)] as well as blood eosinophil count and C-reactive protein were used as dependent variables to test the association with alcohol groups including multivariable linear regression models with adjustment for predictors of FENO. Results Excessive alcohol consumption comprised 3,693 (26.9%) of the US sample population. Controlling for all other factors, excessive alcohol consumption had a negative association and was an independent predictor for ln(FENO) levels in comparison with the never-drinker group (−0.11; 95% CI, −0.17 to −0.06; P <.001). ln(FENO) levels decreased across categories of increasing alcohol use (P <.001). Conclusions Accounting for alcohol use in the interpretation of FENO levels should be an additional consideration, and further investigations are warranted to explore the complex interaction between alcohol and nitric oxide in the airways.

Original languageEnglish (US)
Pages (from-to)196-209
Number of pages14
JournalChest
Volume150
Issue number1
DOIs
StatePublished - Jul 1 2016

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Alcohol Drinking
Nitric Oxide
Alcohols
Linear Models
Health Surveys
Eosinophils
C-Reactive Protein
Population
Lung Diseases

Keywords

  • airway inflammation
  • alcohol
  • C-reactive protein
  • epidemiology (pulmonary)
  • exhaled nitric oxide

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Exhaled Nitric Oxide Levels Among Adults With Excessive Alcohol Consumption. / Afshar, Majid; Poole, Jill A; Cao, Guichan; Durazo, Ramon; Cooper, Richard C.; Kovacs, Elizabeth J.; Sisson, Joseph Harold.

In: Chest, Vol. 150, No. 1, 01.07.2016, p. 196-209.

Research output: Contribution to journalArticle

Afshar, Majid ; Poole, Jill A ; Cao, Guichan ; Durazo, Ramon ; Cooper, Richard C. ; Kovacs, Elizabeth J. ; Sisson, Joseph Harold. / Exhaled Nitric Oxide Levels Among Adults With Excessive Alcohol Consumption. In: Chest. 2016 ; Vol. 150, No. 1. pp. 196-209.
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abstract = "Background More than one-quarter of the US population qualify as excessive alcohol consumers. Alcohol use impacts several lung diseases, and heavy consumption has been associated with poor clinical outcomes. The fractional excretion of exhaled nitric oxide (FENO) has clinical implications in multiple airways diseases. We hypothesized that excessive alcohol intake is associated with lower FENO levels. Methods To test this hypothesis, we examined a sample consisting of 12,059 participants, aged 21 to 79 years, interviewed between 2007 and 2012 from the National Health and Examination Survey. Two valid FENO measurements that were reproducible were recorded. Alcohol questionnaire data were used to define the following alcohol groups: never drinkers, nonexcessive drinkers, excessive drinkers, and former excessive drinkers. The natural logarithm of FENO values [ln(FENO)] as well as blood eosinophil count and C-reactive protein were used as dependent variables to test the association with alcohol groups including multivariable linear regression models with adjustment for predictors of FENO. Results Excessive alcohol consumption comprised 3,693 (26.9{\%}) of the US sample population. Controlling for all other factors, excessive alcohol consumption had a negative association and was an independent predictor for ln(FENO) levels in comparison with the never-drinker group (−0.11; 95{\%} CI, −0.17 to −0.06; P <.001). ln(FENO) levels decreased across categories of increasing alcohol use (P <.001). Conclusions Accounting for alcohol use in the interpretation of FENO levels should be an additional consideration, and further investigations are warranted to explore the complex interaction between alcohol and nitric oxide in the airways.",
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N2 - Background More than one-quarter of the US population qualify as excessive alcohol consumers. Alcohol use impacts several lung diseases, and heavy consumption has been associated with poor clinical outcomes. The fractional excretion of exhaled nitric oxide (FENO) has clinical implications in multiple airways diseases. We hypothesized that excessive alcohol intake is associated with lower FENO levels. Methods To test this hypothesis, we examined a sample consisting of 12,059 participants, aged 21 to 79 years, interviewed between 2007 and 2012 from the National Health and Examination Survey. Two valid FENO measurements that were reproducible were recorded. Alcohol questionnaire data were used to define the following alcohol groups: never drinkers, nonexcessive drinkers, excessive drinkers, and former excessive drinkers. The natural logarithm of FENO values [ln(FENO)] as well as blood eosinophil count and C-reactive protein were used as dependent variables to test the association with alcohol groups including multivariable linear regression models with adjustment for predictors of FENO. Results Excessive alcohol consumption comprised 3,693 (26.9%) of the US sample population. Controlling for all other factors, excessive alcohol consumption had a negative association and was an independent predictor for ln(FENO) levels in comparison with the never-drinker group (−0.11; 95% CI, −0.17 to −0.06; P <.001). ln(FENO) levels decreased across categories of increasing alcohol use (P <.001). Conclusions Accounting for alcohol use in the interpretation of FENO levels should be an additional consideration, and further investigations are warranted to explore the complex interaction between alcohol and nitric oxide in the airways.

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