Exercise training improves cardiac autonomic control, cardiac function, and arrhythmogenesis in rats with preserved-ejection fraction heart failure

David C. Andrade, Alexis Arce-Alvarez, Camilo Toledo, Hugo S. Díaz, Claudia Lucero, Harold D. Schultz, Noah J. Marcus, Rodrigo Del Rio

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Chronic heart failure is characterized by autonomic imbalance, cardiac dysfunction, and arrhythmogenesis. It has been shown that exercise training (ExT) improves central nervous system oxidative stress, autonomic control, and cardiac function in heart failure with reduced ejection fraction; however, to date no comprehensive studies have addressed the effects of ExT, if any, on oxidative stress in brain stem cardiovascular areas, cardiac autonomic balance, arrhythmogenesis, and cardiac function in heart failure with preserved ejection fraction (HFpEF). We hypothesize that ExT reduces brain stem oxidative stress, improves cardiac autonomic control and cardiac function, and reduces arrhythmogenesis in HFpEF rats. Rats underwent sham treatment or volume overload to induce HFpEF. ExT (60 min/day, 25 m/min, 10% inclination) was performed for 6 wk starting at the second week after HFpEF induction. Rats were randomly allocated into Shamsedentary (Sed) (n 8), ShamExT (n 6), HFpEFSed (n 8), and HFpEFExT (n 8) groups. Compared with the HFpEFSed condition, HFpEFExT rats displayed reduced NAD(P)H oxidase activity and oxidative stress in the rostral ventrolateral medulla (RVLM), improved cardiac autonomic balance, and reduced arrhythmogenesis. Furthermore, a threefold improvement in cardiac function was observed in HFpEFExT rats. These novel findings suggest that moderate-intensity ExT is an effective means to attenuate the progression of HFpEF through improvement in RVLM redox state, cardiac autonomic control, and cardiac function.

Original languageEnglish (US)
Pages (from-to)567-577
Number of pages11
JournalJournal of Applied Physiology
Volume123
Issue number3
DOIs
StatePublished - Sep 2017

Fingerprint

Heart Failure
Exercise
Oxidative Stress
Brain Stem
NADPH Oxidase
Oxidation-Reduction
Central Nervous System
Placebos

Keywords

  • Arrhythmogenesis
  • Autonomic control
  • Exercise training
  • Heart failure with preserved ejection fraction

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Exercise training improves cardiac autonomic control, cardiac function, and arrhythmogenesis in rats with preserved-ejection fraction heart failure. / Andrade, David C.; Arce-Alvarez, Alexis; Toledo, Camilo; Díaz, Hugo S.; Lucero, Claudia; Schultz, Harold D.; Marcus, Noah J.; Rio, Rodrigo Del.

In: Journal of Applied Physiology, Vol. 123, No. 3, 09.2017, p. 567-577.

Research output: Contribution to journalArticle

Andrade, David C. ; Arce-Alvarez, Alexis ; Toledo, Camilo ; Díaz, Hugo S. ; Lucero, Claudia ; Schultz, Harold D. ; Marcus, Noah J. ; Rio, Rodrigo Del. / Exercise training improves cardiac autonomic control, cardiac function, and arrhythmogenesis in rats with preserved-ejection fraction heart failure. In: Journal of Applied Physiology. 2017 ; Vol. 123, No. 3. pp. 567-577.
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