Exercise improves host response to influenza viral infection in obese and non-obese mice through different mechanisms

Kristi J. Warren, Molly M. Olson, Nicholas J. Thompson, Mackenzie L. Cahill, Todd A Wyatt, Kyoungjin J. Yoon, Christina M. Loiacono, Marian L. Kohut

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Obesity has been associated with greater severity of influenza virus infection and impaired host defense. Exercise may confer health benefits even when weight loss is not achieved, but it has not been determined if regular exercise improves immune defense against influenza A virus (IAV) in the obese condition. In this study, diet-induced obese mice and lean control mice exercised for eight weeks followed by influenza viral infection. Exercise reduced disease severity in both obese and non-obese mice, but the mechanisms differed. Exercise reversed the obesity-associated delay in bronchoalveolar-lavage (BAL) cell infiltration, restored BAL cytokine and chemokine production, and increased ciliary beat frequency and IFNα-related gene expression. In non-obese mice, exercise treatment reduced lung viral load, increased Type-I-IFN-related gene expression early during infection, but reduced BAL inflammatory cytokines and chemokines. In both obese and non-obese mice, exercise increased serum anti-influenza virus specific IgG2c antibody, increased CD8+ T cell percentage in BAL, and reduced TNFα by influenza viral NP-peptide-responding CD8+ T cells. Overall, the results suggest that exercise "restores" the immune response of obese mice to a phenotype similar to non-obese mice by improving the delay in immune activation. In contrast, in non-obese mice exercise treatment results in an early reduction in lung viral load and limited inflammatory response.

Original languageEnglish (US)
Article numbere0129713
JournalPloS one
Volume10
Issue number6
DOIs
StatePublished - Jun 25 2015

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Virus Diseases
Viruses
influenza
Human Influenza
exercise
T-cells
Bronchoalveolar Lavage
Chemokines
Gene expression
mice
infection
Cytokines
Obese Mice
Nutrition
Orthomyxoviridae
Viral Load
Infiltration
chemokines
Obesity
viral load

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Warren, K. J., Olson, M. M., Thompson, N. J., Cahill, M. L., Wyatt, T. A., Yoon, K. J., ... Kohut, M. L. (2015). Exercise improves host response to influenza viral infection in obese and non-obese mice through different mechanisms. PloS one, 10(6), [e0129713]. https://doi.org/10.1371/journal.pone.0129713

Exercise improves host response to influenza viral infection in obese and non-obese mice through different mechanisms. / Warren, Kristi J.; Olson, Molly M.; Thompson, Nicholas J.; Cahill, Mackenzie L.; Wyatt, Todd A; Yoon, Kyoungjin J.; Loiacono, Christina M.; Kohut, Marian L.

In: PloS one, Vol. 10, No. 6, e0129713, 25.06.2015.

Research output: Contribution to journalArticle

Warren, KJ, Olson, MM, Thompson, NJ, Cahill, ML, Wyatt, TA, Yoon, KJ, Loiacono, CM & Kohut, ML 2015, 'Exercise improves host response to influenza viral infection in obese and non-obese mice through different mechanisms', PloS one, vol. 10, no. 6, e0129713. https://doi.org/10.1371/journal.pone.0129713
Warren, Kristi J. ; Olson, Molly M. ; Thompson, Nicholas J. ; Cahill, Mackenzie L. ; Wyatt, Todd A ; Yoon, Kyoungjin J. ; Loiacono, Christina M. ; Kohut, Marian L. / Exercise improves host response to influenza viral infection in obese and non-obese mice through different mechanisms. In: PloS one. 2015 ; Vol. 10, No. 6.
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