Excitatory amino acid receptors and ischemic brain damage in the rat

Eva Westerberg, Daniel T. Monaghan, Carl W. Cotman, Tadeusz Wieloch

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The excitatory amino acid glutamate has been suggested to be an important mediator of the selective CA1 hippocampal damage which follows transient cerebral ischemia. In order to evaluate the possible involvement of altered glutamate receptor regulation in the expression of the delayed neuronal necrosis following ischemia, we have determined the density of glutamate receptor subtypes in the rat hippocampus following transient ischemia. We report a transient reversible decrease in [3H]AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) binding sites (presumably representing quisqualate receptors) followed by a long term loss of binding at 2 days postischemia which precedes neuronal loss. In contrast, no change was noted in the N-methyl-d-aspartate or kainic acid binding sites over this time period.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalNeuroscience Letters
Volume73
Issue number2
DOIs
Publication statusPublished - Jan 14 1987

    Fingerprint

Keywords

  • Brain damage
  • Glutamate receptor
  • Hippocampus
  • Ischemia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this