Examining fatigue in COPD

development, validity and reliability of a modified version of FACIT-F scale

Khaled Al-shair, Hana Muellerova, Janelle Yorke, Stephen Israel Rennard, Emiel F.M. Wouters, Nicola A. Hanania, Amir Sharafkhaneh, Jørgen Vestbo

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Introduction: Fatigue is a disruptive symptom that inhibits normal functional performance of COPD patients in daily activities. The availability of a short, simple, reliable and valid scale would improve assessment of the characteristics and influence of fatigue in COPD.Methods: At baseline, 2107 COPD patients from the ECLIPSE cohort completed the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) scale. We used well-structured classic method, the principal components analysis (PCA) and Rasch analysis for structurally examining the 13-item FACIT-F.Results: Four items were less able to capture fatigue characteristics in COPD and were deleted. PCA was applied to the remaining 9 items of the modified FACIT-F and resulted in three interpretable dimensions: i) general (5 items); ii) functional ability (2 items); and iii) psychosocial fatigue (2 items). The modified FACIT-F had high internal consistency (Cronbach's α = 0.91) and it did not fit a uni-dimensional Rasch model, confirming the prior output from the PCA. The correlations between total score and each dimension were ≥ 0.64 and within dimensions ≥0.43 (p < 0.001 for all).The original and modified FACIT-F had significant convergent validity; its scores were associated with SGRQ total score (0.69 and 0.7) and mMRC dyspnoea scores (0.48 and 0.47), (p = <0.001 for all). The scale had meaningful discriminating ability in identifying patients with poor exercise performance and more depressive symptoms.Conclusion: The original and modified FACIT-F are valid and reliable scales in COPD. The modified version is shorter and measures not only total fatigue but also its sub-components in COPD.

Original languageEnglish (US)
Article number100
JournalHealth and Quality of Life Outcomes
Volume10
DOIs
StatePublished - Aug 23 2012

Fingerprint

Reproducibility of Results
Chronic Obstructive Pulmonary Disease
Fatigue
Chronic Disease
Principal Component Analysis
Therapeutics
Aptitude
Dyspnea
Exercise
Depression

Keywords

  • Chronic obstructive pulmonary disease
  • Exercise capacity
  • Fatigue
  • Health status

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Al-shair, K., Muellerova, H., Yorke, J., Rennard, S. I., Wouters, E. F. M., Hanania, N. A., ... Vestbo, J. (2012). Examining fatigue in COPD: development, validity and reliability of a modified version of FACIT-F scale. Health and Quality of Life Outcomes, 10, [100]. https://doi.org/10.1186/1477-7525-10-100

Examining fatigue in COPD : development, validity and reliability of a modified version of FACIT-F scale. / Al-shair, Khaled; Muellerova, Hana; Yorke, Janelle; Rennard, Stephen Israel; Wouters, Emiel F.M.; Hanania, Nicola A.; Sharafkhaneh, Amir; Vestbo, Jørgen.

In: Health and Quality of Life Outcomes, Vol. 10, 100, 23.08.2012.

Research output: Contribution to journalArticle

Al-shair, K, Muellerova, H, Yorke, J, Rennard, SI, Wouters, EFM, Hanania, NA, Sharafkhaneh, A & Vestbo, J 2012, 'Examining fatigue in COPD: development, validity and reliability of a modified version of FACIT-F scale', Health and Quality of Life Outcomes, vol. 10, 100. https://doi.org/10.1186/1477-7525-10-100
Al-shair, Khaled ; Muellerova, Hana ; Yorke, Janelle ; Rennard, Stephen Israel ; Wouters, Emiel F.M. ; Hanania, Nicola A. ; Sharafkhaneh, Amir ; Vestbo, Jørgen. / Examining fatigue in COPD : development, validity and reliability of a modified version of FACIT-F scale. In: Health and Quality of Life Outcomes. 2012 ; Vol. 10.
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abstract = "Introduction: Fatigue is a disruptive symptom that inhibits normal functional performance of COPD patients in daily activities. The availability of a short, simple, reliable and valid scale would improve assessment of the characteristics and influence of fatigue in COPD.Methods: At baseline, 2107 COPD patients from the ECLIPSE cohort completed the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) scale. We used well-structured classic method, the principal components analysis (PCA) and Rasch analysis for structurally examining the 13-item FACIT-F.Results: Four items were less able to capture fatigue characteristics in COPD and were deleted. PCA was applied to the remaining 9 items of the modified FACIT-F and resulted in three interpretable dimensions: i) general (5 items); ii) functional ability (2 items); and iii) psychosocial fatigue (2 items). The modified FACIT-F had high internal consistency (Cronbach's α = 0.91) and it did not fit a uni-dimensional Rasch model, confirming the prior output from the PCA. The correlations between total score and each dimension were ≥ 0.64 and within dimensions ≥0.43 (p < 0.001 for all).The original and modified FACIT-F had significant convergent validity; its scores were associated with SGRQ total score (0.69 and 0.7) and mMRC dyspnoea scores (0.48 and 0.47), (p = <0.001 for all). The scale had meaningful discriminating ability in identifying patients with poor exercise performance and more depressive symptoms.Conclusion: The original and modified FACIT-F are valid and reliable scales in COPD. The modified version is shorter and measures not only total fatigue but also its sub-components in COPD.",
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AU - Al-shair, Khaled

AU - Muellerova, Hana

AU - Yorke, Janelle

AU - Rennard, Stephen Israel

AU - Wouters, Emiel F.M.

AU - Hanania, Nicola A.

AU - Sharafkhaneh, Amir

AU - Vestbo, Jørgen

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N2 - Introduction: Fatigue is a disruptive symptom that inhibits normal functional performance of COPD patients in daily activities. The availability of a short, simple, reliable and valid scale would improve assessment of the characteristics and influence of fatigue in COPD.Methods: At baseline, 2107 COPD patients from the ECLIPSE cohort completed the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) scale. We used well-structured classic method, the principal components analysis (PCA) and Rasch analysis for structurally examining the 13-item FACIT-F.Results: Four items were less able to capture fatigue characteristics in COPD and were deleted. PCA was applied to the remaining 9 items of the modified FACIT-F and resulted in three interpretable dimensions: i) general (5 items); ii) functional ability (2 items); and iii) psychosocial fatigue (2 items). The modified FACIT-F had high internal consistency (Cronbach's α = 0.91) and it did not fit a uni-dimensional Rasch model, confirming the prior output from the PCA. The correlations between total score and each dimension were ≥ 0.64 and within dimensions ≥0.43 (p < 0.001 for all).The original and modified FACIT-F had significant convergent validity; its scores were associated with SGRQ total score (0.69 and 0.7) and mMRC dyspnoea scores (0.48 and 0.47), (p = <0.001 for all). The scale had meaningful discriminating ability in identifying patients with poor exercise performance and more depressive symptoms.Conclusion: The original and modified FACIT-F are valid and reliable scales in COPD. The modified version is shorter and measures not only total fatigue but also its sub-components in COPD.

AB - Introduction: Fatigue is a disruptive symptom that inhibits normal functional performance of COPD patients in daily activities. The availability of a short, simple, reliable and valid scale would improve assessment of the characteristics and influence of fatigue in COPD.Methods: At baseline, 2107 COPD patients from the ECLIPSE cohort completed the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) scale. We used well-structured classic method, the principal components analysis (PCA) and Rasch analysis for structurally examining the 13-item FACIT-F.Results: Four items were less able to capture fatigue characteristics in COPD and were deleted. PCA was applied to the remaining 9 items of the modified FACIT-F and resulted in three interpretable dimensions: i) general (5 items); ii) functional ability (2 items); and iii) psychosocial fatigue (2 items). The modified FACIT-F had high internal consistency (Cronbach's α = 0.91) and it did not fit a uni-dimensional Rasch model, confirming the prior output from the PCA. The correlations between total score and each dimension were ≥ 0.64 and within dimensions ≥0.43 (p < 0.001 for all).The original and modified FACIT-F had significant convergent validity; its scores were associated with SGRQ total score (0.69 and 0.7) and mMRC dyspnoea scores (0.48 and 0.47), (p = <0.001 for all). The scale had meaningful discriminating ability in identifying patients with poor exercise performance and more depressive symptoms.Conclusion: The original and modified FACIT-F are valid and reliable scales in COPD. The modified version is shorter and measures not only total fatigue but also its sub-components in COPD.

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