Examination of clonal variants from human malignant melanoma studied by chromosome banding analysis

J. Bridge, S. P. Leong, A. C. Burgess, F. Thompson, J. M. Trent

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Multiple metastatic melanoma lesions from three patients were cytogenetically characterized in order to assess the degree of intra-patient karyotypic heterogeneity. A total of 20 specimens were analysed: 12 samples from patient No. 1, five samples from patient No. 2, and three samples from patient No. 3. Sufficient mitoses were obtained to perform detailed analysis in 19/20 specimens following short-term culture. The modal chromosome number of all three cases was neardiploid, with all samples demonstrating multiple structural abnormalities. Abnormalities shared by all three patients were alterations of chromosomes 1 and 8. Other structural abnormalities common to two of the three patients involved chromosomes 6, 7, 9 and 10. Minor intra-tumour karyotypic variation was detected in all three cases. However, the majority of clonal alterations were retained in all metastatic lesions, clearly indicating the karyotypically stable and clonal nature of this neoplasm.

Original languageEnglish (US)
Pages (from-to)289-296
Number of pages8
JournalMelanoma Research
Volume1
Issue number4
StatePublished - Nov 1991

Fingerprint

Chromosome Banding
Melanoma
Multiple Abnormalities
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 1
Mitosis
Neoplasms
Chromosomes

Keywords

  • Heterogeneity
  • Karyotype
  • Melanoma

ASJC Scopus subject areas

  • Oncology
  • Dermatology
  • Cancer Research

Cite this

Bridge, J., Leong, S. P., Burgess, A. C., Thompson, F., & Trent, J. M. (1991). Examination of clonal variants from human malignant melanoma studied by chromosome banding analysis. Melanoma Research, 1(4), 289-296.

Examination of clonal variants from human malignant melanoma studied by chromosome banding analysis. / Bridge, J.; Leong, S. P.; Burgess, A. C.; Thompson, F.; Trent, J. M.

In: Melanoma Research, Vol. 1, No. 4, 11.1991, p. 289-296.

Research output: Contribution to journalArticle

Bridge, J, Leong, SP, Burgess, AC, Thompson, F & Trent, JM 1991, 'Examination of clonal variants from human malignant melanoma studied by chromosome banding analysis', Melanoma Research, vol. 1, no. 4, pp. 289-296.
Bridge J, Leong SP, Burgess AC, Thompson F, Trent JM. Examination of clonal variants from human malignant melanoma studied by chromosome banding analysis. Melanoma Research. 1991 Nov;1(4):289-296.
Bridge, J. ; Leong, S. P. ; Burgess, A. C. ; Thompson, F. ; Trent, J. M. / Examination of clonal variants from human malignant melanoma studied by chromosome banding analysis. In: Melanoma Research. 1991 ; Vol. 1, No. 4. pp. 289-296.
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