Exacerbation of inflammatory demyelinating polyneuropathy after bone marrow transplantation

H. Openshaw, D. R. Hinton, N. E. Slatkin, P. J. Bierman, F. M. Hoffman, D. S. Snyder

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Abstract

Two patients with hematologic malignancy and quiescent inflammatory demyelinating polyneuropathy developed severe exacerbations of polyneuropathy at the time of bone marrow transplantation. The clinical course in both patients was progressive despite therapy with immunosuppressive agents, plasmapheresis, and high dose immunoglobulin. The polyneuropathy resulted in quadriplegia which contributed to the patients' deaths 175 and 48 days after transplantation. Sections of multiple peripheral nerves sampled post mortem in the first case revealed prominent demyelination with heavy infiltration of mactophages and lymphocytes. Immunohistochemical studies demonstrated that most of the lymphocytes were of the CD8+, cytotoxic/suppressor cell class and that many of the Schwann cells expressed class II (HLA-DR) antigen. This report suggests that bone marrow transplantation can exacerbate inflammatory demyelinating polyneuropathy.

Original languageEnglish (US)
Pages (from-to)411-414
Number of pages4
JournalBone marrow transplantation
Volume7
Issue number5
Publication statusPublished - Jan 1 1991

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ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Openshaw, H., Hinton, D. R., Slatkin, N. E., Bierman, P. J., Hoffman, F. M., & Snyder, D. S. (1991). Exacerbation of inflammatory demyelinating polyneuropathy after bone marrow transplantation. Bone marrow transplantation, 7(5), 411-414.