EWS/FLI-1 fusion signal inserted into chromosome 11 in one patient with morphologic features of Ewing sarcoma, but lacking t(11;22)

Jacqueline R. Batanian, Julia A. Bridge, Robert Wickert, Carol Vogler, Bharti Gadre, Yufeng Huang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A reciprocal t(11;22)(q24;q12) is found in 85% of Ewing sarcomas (ES) cases. We report a case of a child with ES, in whom trisomy 8 was observed as the sole chromosomal abnormality. Fluorescence in situ hybridization - using a set of probes that localize to 22q12 (EWS) and 11q24 (FLI-1) and usually show the translocation as fusion (red-green) signal on der(22) - showed a fusion signal on der(11) suggesting an insertion as the mechanism that led to the EWS-FLI-1 gene rearrangement. Reverse transcriptase-polymerase chain reaction studies revealed the presence of two EWS/FLI1 fusion gene products.

Original languageEnglish (US)
Pages (from-to)72-75
Number of pages4
JournalCancer genetics and cytogenetics
Volume133
Issue number1
DOIs
StatePublished - Mar 25 2002

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Chromosomes, Human, Pair 11
Ewing's Sarcoma
Gene Rearrangement
Gene Fusion
Reverse Transcriptase Polymerase Chain Reaction
Fluorescence In Situ Hybridization
Chromosome Aberrations
EWS-FLI fusion protein

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

EWS/FLI-1 fusion signal inserted into chromosome 11 in one patient with morphologic features of Ewing sarcoma, but lacking t(11;22). / Batanian, Jacqueline R.; Bridge, Julia A.; Wickert, Robert; Vogler, Carol; Gadre, Bharti; Huang, Yufeng.

In: Cancer genetics and cytogenetics, Vol. 133, No. 1, 25.03.2002, p. 72-75.

Research output: Contribution to journalArticle

Batanian, Jacqueline R. ; Bridge, Julia A. ; Wickert, Robert ; Vogler, Carol ; Gadre, Bharti ; Huang, Yufeng. / EWS/FLI-1 fusion signal inserted into chromosome 11 in one patient with morphologic features of Ewing sarcoma, but lacking t(11;22). In: Cancer genetics and cytogenetics. 2002 ; Vol. 133, No. 1. pp. 72-75.
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