Ewing's sarcoma of soft tissues in childhood: A report from the Intergroup Rhabdomyosarcoma Study, 1972 to 1991

R. B. Raney, L. Asmar, Jr A. Newton, C. Bagwell, J. C. Breneman, W. Crist, E. A. Gehan, B. Webber, M. Wharam, E. S. Wiener, J. R. Anderson, H. M. Maurer

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Abstract

Purpose: One hundred thirty of 2,792 patients (5%) registered on three Intergroup Rhabdomyosarcoma Study clinical trials (IRS-I, -II, and III) from 1972 to 1991 had an extraosseous Ewing's sarcoma (EOE). We report here the results of multimodality therapy for this tumor. Patients and Methods: The 130 patients were less than 21 years of age; 70 (54%) were males. Primary tumor sites were an the trunk in 41 patients, an extremity in 34, the head/neck in 23, the retroperitoneum/pelvis in 21, and other sites in 11. One hundred fourteen patients had no metastases at diagnosis. In 21 patients, the tumor was completely resected; in 30, the localized or regional tumor was grossly resected, and in 63 patients, grossly visible sarcoma was left behind. Sixteen patients (12%) had distant metastases at diagnosis. All patients were given multiagent chemotherapy and most received irradiation (XRT); none were treated with bone marrow transplantation. Results: One hundred seven patients (82%) achieved a complete response. At 10 years, 62%, 61%, and 77% of the patients were alive after treatment on IRS-I, IRS-II, or IRS-III therapeutic protocols, respectively, similar to figures obtained in all IRS patients. At last follow-up evaluation, 42 patients had died of progressive tumor and one of infection. Survival at 10 years was most likely for patients with tumor that arose in the head and neck, extremities, and trunk, and for those who underwent grossly complete tumor removal before initiation of chemotherapy. For patients with localized, grass residual tumor, adding doxorubicin (DOX) to the combination of vincristine, doctinomycin, cyclophosphamide (VAC), and XRT did not significantly improve survival in 39 patients (62% alive at 10 years) compared with that of 24 patients treated with VAC and XRT without DOX (65% alive at 10 years, P = .93). Conclusion: This series indicated that EOE in children is similar to rhabdomyosarcoma (RMS) in its response to multimodal treatment. No benefit was apparent from the addition of DOX to VAC chemotherapy in patients with gross residual EOE.

Original languageEnglish (US)
Pages (from-to)574-582
Number of pages9
JournalJournal of Clinical Oncology
Volume15
Issue number2
DOIs
StatePublished - Feb 1997

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Ewing's Sarcoma
Rhabdomyosarcoma
Neoplasms
Doxorubicin
Drug Therapy
Neck
Extremities
Head
Neoplasm Metastasis
Combined Modality Therapy
Survival
Residual Neoplasm

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Raney, R. B., Asmar, L., Newton, J. A., Bagwell, C., Breneman, J. C., Crist, W., ... Maurer, H. M. (1997). Ewing's sarcoma of soft tissues in childhood: A report from the Intergroup Rhabdomyosarcoma Study, 1972 to 1991. Journal of Clinical Oncology, 15(2), 574-582. https://doi.org/10.1200/JCO.1997.15.2.574

Ewing's sarcoma of soft tissues in childhood : A report from the Intergroup Rhabdomyosarcoma Study, 1972 to 1991. / Raney, R. B.; Asmar, L.; Newton, Jr A.; Bagwell, C.; Breneman, J. C.; Crist, W.; Gehan, E. A.; Webber, B.; Wharam, M.; Wiener, E. S.; Anderson, J. R.; Maurer, H. M.

In: Journal of Clinical Oncology, Vol. 15, No. 2, 02.1997, p. 574-582.

Research output: Contribution to journalArticle

Raney, RB, Asmar, L, Newton, JA, Bagwell, C, Breneman, JC, Crist, W, Gehan, EA, Webber, B, Wharam, M, Wiener, ES, Anderson, JR & Maurer, HM 1997, 'Ewing's sarcoma of soft tissues in childhood: A report from the Intergroup Rhabdomyosarcoma Study, 1972 to 1991', Journal of Clinical Oncology, vol. 15, no. 2, pp. 574-582. https://doi.org/10.1200/JCO.1997.15.2.574
Raney, R. B. ; Asmar, L. ; Newton, Jr A. ; Bagwell, C. ; Breneman, J. C. ; Crist, W. ; Gehan, E. A. ; Webber, B. ; Wharam, M. ; Wiener, E. S. ; Anderson, J. R. ; Maurer, H. M. / Ewing's sarcoma of soft tissues in childhood : A report from the Intergroup Rhabdomyosarcoma Study, 1972 to 1991. In: Journal of Clinical Oncology. 1997 ; Vol. 15, No. 2. pp. 574-582.
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abstract = "Purpose: One hundred thirty of 2,792 patients (5{\%}) registered on three Intergroup Rhabdomyosarcoma Study clinical trials (IRS-I, -II, and III) from 1972 to 1991 had an extraosseous Ewing's sarcoma (EOE). We report here the results of multimodality therapy for this tumor. Patients and Methods: The 130 patients were less than 21 years of age; 70 (54{\%}) were males. Primary tumor sites were an the trunk in 41 patients, an extremity in 34, the head/neck in 23, the retroperitoneum/pelvis in 21, and other sites in 11. One hundred fourteen patients had no metastases at diagnosis. In 21 patients, the tumor was completely resected; in 30, the localized or regional tumor was grossly resected, and in 63 patients, grossly visible sarcoma was left behind. Sixteen patients (12{\%}) had distant metastases at diagnosis. All patients were given multiagent chemotherapy and most received irradiation (XRT); none were treated with bone marrow transplantation. Results: One hundred seven patients (82{\%}) achieved a complete response. At 10 years, 62{\%}, 61{\%}, and 77{\%} of the patients were alive after treatment on IRS-I, IRS-II, or IRS-III therapeutic protocols, respectively, similar to figures obtained in all IRS patients. At last follow-up evaluation, 42 patients had died of progressive tumor and one of infection. Survival at 10 years was most likely for patients with tumor that arose in the head and neck, extremities, and trunk, and for those who underwent grossly complete tumor removal before initiation of chemotherapy. For patients with localized, grass residual tumor, adding doxorubicin (DOX) to the combination of vincristine, doctinomycin, cyclophosphamide (VAC), and XRT did not significantly improve survival in 39 patients (62{\%} alive at 10 years) compared with that of 24 patients treated with VAC and XRT without DOX (65{\%} alive at 10 years, P = .93). Conclusion: This series indicated that EOE in children is similar to rhabdomyosarcoma (RMS) in its response to multimodal treatment. No benefit was apparent from the addition of DOX to VAC chemotherapy in patients with gross residual EOE.",
author = "Raney, {R. B.} and L. Asmar and Newton, {Jr A.} and C. Bagwell and Breneman, {J. C.} and W. Crist and Gehan, {E. A.} and B. Webber and M. Wharam and Wiener, {E. S.} and Anderson, {J. R.} and Maurer, {H. M.}",
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T2 - A report from the Intergroup Rhabdomyosarcoma Study, 1972 to 1991

AU - Raney, R. B.

AU - Asmar, L.

AU - Newton, Jr A.

AU - Bagwell, C.

AU - Breneman, J. C.

AU - Crist, W.

AU - Gehan, E. A.

AU - Webber, B.

AU - Wharam, M.

AU - Wiener, E. S.

AU - Anderson, J. R.

AU - Maurer, H. M.

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N2 - Purpose: One hundred thirty of 2,792 patients (5%) registered on three Intergroup Rhabdomyosarcoma Study clinical trials (IRS-I, -II, and III) from 1972 to 1991 had an extraosseous Ewing's sarcoma (EOE). We report here the results of multimodality therapy for this tumor. Patients and Methods: The 130 patients were less than 21 years of age; 70 (54%) were males. Primary tumor sites were an the trunk in 41 patients, an extremity in 34, the head/neck in 23, the retroperitoneum/pelvis in 21, and other sites in 11. One hundred fourteen patients had no metastases at diagnosis. In 21 patients, the tumor was completely resected; in 30, the localized or regional tumor was grossly resected, and in 63 patients, grossly visible sarcoma was left behind. Sixteen patients (12%) had distant metastases at diagnosis. All patients were given multiagent chemotherapy and most received irradiation (XRT); none were treated with bone marrow transplantation. Results: One hundred seven patients (82%) achieved a complete response. At 10 years, 62%, 61%, and 77% of the patients were alive after treatment on IRS-I, IRS-II, or IRS-III therapeutic protocols, respectively, similar to figures obtained in all IRS patients. At last follow-up evaluation, 42 patients had died of progressive tumor and one of infection. Survival at 10 years was most likely for patients with tumor that arose in the head and neck, extremities, and trunk, and for those who underwent grossly complete tumor removal before initiation of chemotherapy. For patients with localized, grass residual tumor, adding doxorubicin (DOX) to the combination of vincristine, doctinomycin, cyclophosphamide (VAC), and XRT did not significantly improve survival in 39 patients (62% alive at 10 years) compared with that of 24 patients treated with VAC and XRT without DOX (65% alive at 10 years, P = .93). Conclusion: This series indicated that EOE in children is similar to rhabdomyosarcoma (RMS) in its response to multimodal treatment. No benefit was apparent from the addition of DOX to VAC chemotherapy in patients with gross residual EOE.

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