Ewing Sarcoma with 7;22 translocation: Three new cases and clinicopathological characterization

Sarah Catherine Shulman, Howard Katzenstein, Julia Bridge, Lucas L. Bannister, Muna Qayed, Shervin Oskouei, Bahig M. Shehata

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Ewing sarcoma (ES) is the second most common primary bone malignancy in children and is typically characterized by a translocation involving the EWS gene on chromosome 22 and a member of the ETS family of genes: FLI1 (90), ERG1 (5), ETV1 (1), ETV4 (1), and FEV (1). We identified three new cases of t(7;22) (p22;q12) (EWS-ETV1) ES and a literature search revealed an additional six cases. In comparison to conventional ES with t(11;22) (q24;q12) (EWS-FLI1), the t(7;22) ES variant has a higher propensity for females and children in a younger age group and it occurs more commonly in extraosseous locations.

Original languageEnglish (US)
Pages (from-to)341-348
Number of pages8
JournalFetal and Pediatric Pathology
Volume31
Issue number6
DOIs
StatePublished - Dec 1 2012

Fingerprint

Ewing's Sarcoma
Chromosomes, Human, Pair 22
Genes
Age Groups
Bone and Bones
Neoplasms

Keywords

  • Ewing sarcoma (ES)
  • T(7;22)
  • Translocation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Shulman, S. C., Katzenstein, H., Bridge, J., Bannister, L. L., Qayed, M., Oskouei, S., & Shehata, B. M. (2012). Ewing Sarcoma with 7;22 translocation: Three new cases and clinicopathological characterization. Fetal and Pediatric Pathology, 31(6), 341-348. https://doi.org/10.3109/15513815.2012.659397

Ewing Sarcoma with 7;22 translocation : Three new cases and clinicopathological characterization. / Shulman, Sarah Catherine; Katzenstein, Howard; Bridge, Julia; Bannister, Lucas L.; Qayed, Muna; Oskouei, Shervin; Shehata, Bahig M.

In: Fetal and Pediatric Pathology, Vol. 31, No. 6, 01.12.2012, p. 341-348.

Research output: Contribution to journalArticle

Shulman, SC, Katzenstein, H, Bridge, J, Bannister, LL, Qayed, M, Oskouei, S & Shehata, BM 2012, 'Ewing Sarcoma with 7;22 translocation: Three new cases and clinicopathological characterization', Fetal and Pediatric Pathology, vol. 31, no. 6, pp. 341-348. https://doi.org/10.3109/15513815.2012.659397
Shulman, Sarah Catherine ; Katzenstein, Howard ; Bridge, Julia ; Bannister, Lucas L. ; Qayed, Muna ; Oskouei, Shervin ; Shehata, Bahig M. / Ewing Sarcoma with 7;22 translocation : Three new cases and clinicopathological characterization. In: Fetal and Pediatric Pathology. 2012 ; Vol. 31, No. 6. pp. 341-348.
@article{f20ac1739f964895bde8f6e4cec6c8f8,
title = "Ewing Sarcoma with 7;22 translocation: Three new cases and clinicopathological characterization",
abstract = "Ewing sarcoma (ES) is the second most common primary bone malignancy in children and is typically characterized by a translocation involving the EWS gene on chromosome 22 and a member of the ETS family of genes: FLI1 (90), ERG1 (5), ETV1 (1), ETV4 (1), and FEV (1). We identified three new cases of t(7;22) (p22;q12) (EWS-ETV1) ES and a literature search revealed an additional six cases. In comparison to conventional ES with t(11;22) (q24;q12) (EWS-FLI1), the t(7;22) ES variant has a higher propensity for females and children in a younger age group and it occurs more commonly in extraosseous locations.",
keywords = "Ewing sarcoma (ES), T(7;22), Translocation",
author = "Shulman, {Sarah Catherine} and Howard Katzenstein and Julia Bridge and Bannister, {Lucas L.} and Muna Qayed and Shervin Oskouei and Shehata, {Bahig M.}",
year = "2012",
month = "12",
day = "1",
doi = "10.3109/15513815.2012.659397",
language = "English (US)",
volume = "31",
pages = "341--348",
journal = "Fetal and Pediatric Pathology",
issn = "1551-3815",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Ewing Sarcoma with 7;22 translocation

T2 - Three new cases and clinicopathological characterization

AU - Shulman, Sarah Catherine

AU - Katzenstein, Howard

AU - Bridge, Julia

AU - Bannister, Lucas L.

AU - Qayed, Muna

AU - Oskouei, Shervin

AU - Shehata, Bahig M.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Ewing sarcoma (ES) is the second most common primary bone malignancy in children and is typically characterized by a translocation involving the EWS gene on chromosome 22 and a member of the ETS family of genes: FLI1 (90), ERG1 (5), ETV1 (1), ETV4 (1), and FEV (1). We identified three new cases of t(7;22) (p22;q12) (EWS-ETV1) ES and a literature search revealed an additional six cases. In comparison to conventional ES with t(11;22) (q24;q12) (EWS-FLI1), the t(7;22) ES variant has a higher propensity for females and children in a younger age group and it occurs more commonly in extraosseous locations.

AB - Ewing sarcoma (ES) is the second most common primary bone malignancy in children and is typically characterized by a translocation involving the EWS gene on chromosome 22 and a member of the ETS family of genes: FLI1 (90), ERG1 (5), ETV1 (1), ETV4 (1), and FEV (1). We identified three new cases of t(7;22) (p22;q12) (EWS-ETV1) ES and a literature search revealed an additional six cases. In comparison to conventional ES with t(11;22) (q24;q12) (EWS-FLI1), the t(7;22) ES variant has a higher propensity for females and children in a younger age group and it occurs more commonly in extraosseous locations.

KW - Ewing sarcoma (ES)

KW - T(7;22)

KW - Translocation

UR - http://www.scopus.com/inward/record.url?scp=84867728037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867728037&partnerID=8YFLogxK

U2 - 10.3109/15513815.2012.659397

DO - 10.3109/15513815.2012.659397

M3 - Article

C2 - 22432475

AN - SCOPUS:84867728037

VL - 31

SP - 341

EP - 348

JO - Fetal and Pediatric Pathology

JF - Fetal and Pediatric Pathology

SN - 1551-3815

IS - 6

ER -