Evolutionary origin of human and simian immunodeficiency viruses

Takashi Gojobori, Etsuko N. Moriyama, Yasuo Ina, Kazuho Ikeo, Tomoyuki Miura, Hajime Tsujimoto, Masanori Hayami, Shozo Yokoyama

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

From what viruses the human immunodeficiency viruses (HIVs) originated is an extremely controversial question. To address this question, we have analyzed nucleotide sequences of simian immunodeficiency viruses (SIVs) and HIVs by using the techniques for understanding molecular evolution. In particular, we compared the nucleotide sequences of whole genomes, gene region by gene region, between a given pair of viruses, including four types of SIVs - isolated from mandrills (Papio sphinx), African green monkeys (Cercopithecus aethiops), sooty mangabeys (Cercocebus atys), and rhesus macaques (Macaco mulatto) - as well as HIVs. Phylogenetic trees for all gene regions examined showed that the present HIVs may have emerged as different variants of SIVs of Old World monkeys, possibly from recombination between viruses related to SIVs.

Original languageEnglish (US)
Pages (from-to)4108-4111
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume87
Issue number11
DOIs
StatePublished - Jan 1 1990

Fingerprint

Simian Immunodeficiency Virus
Cercocebus atys
HIV
Cercopithecus aethiops
Viruses
Cercopithecidae
Genes
Mandrillus
Molecular Evolution
Papio
Macaca mulatta
Genetic Recombination
Genome

Keywords

  • Molecular evolution
  • Phylogeny
  • Primate lentiviruses
  • Recombination

ASJC Scopus subject areas

  • General

Cite this

Evolutionary origin of human and simian immunodeficiency viruses. / Gojobori, Takashi; Moriyama, Etsuko N.; Ina, Yasuo; Ikeo, Kazuho; Miura, Tomoyuki; Tsujimoto, Hajime; Hayami, Masanori; Yokoyama, Shozo.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 11, 01.01.1990, p. 4108-4111.

Research output: Contribution to journalArticle

Gojobori, Takashi ; Moriyama, Etsuko N. ; Ina, Yasuo ; Ikeo, Kazuho ; Miura, Tomoyuki ; Tsujimoto, Hajime ; Hayami, Masanori ; Yokoyama, Shozo. / Evolutionary origin of human and simian immunodeficiency viruses. In: Proceedings of the National Academy of Sciences of the United States of America. 1990 ; Vol. 87, No. 11. pp. 4108-4111.
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