Evidence that suppression of insulin secretion by insulin itself is neurally mediated

Guenther Boden, Xinhua Chen, Richard DeSantis, Jerzy Kolaczynski, Michael Morris

Research output: Contribution to journalArticle

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Abstract

We examined the mechanism by which an increase in blood insulin concentration inhibits insulin secretion by the pancreas. To this end, we determined plasma C-peptide concentrations during euglycemic-hyperinsulinemic (∼500 pmol/L) clamps in five patients with insulin-dependent diabetes mellitus (IDDM) after combined pancreas and kidney ( P K) transplantation, in five nondiabetic patients after kidney transplantation (K), and in six normal control subjects. Hyperinsulinemia decreased C-peptide concentrations in K patients (by 60%, P < .01) and controls (by 35%, P < .05), but not in P K patients (653 ± 115 v 702 ± 197 pmol/L before and after 4 hours of hyperinsulinemia, respectively). The main difference between K patients and controls and P K patients was that the pancreas in K patients and controls was innervated, whereas the transplanted pancreas of K P patients was denervated. The data therefore suggested that the inhibition of pancreatic insulin secretion by hyperinsulinemia was neurally mediated.

Original languageEnglish (US)
Pages (from-to)786-789
Number of pages4
JournalMetabolism
Volume42
Issue number6
DOIs
StatePublished - Jun 1993

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Insulin
Pancreas
Hyperinsulinism
C-Peptide
Kidney Transplantation
Kidney
Pancreas Transplantation
Type 1 Diabetes Mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Boden, G., Chen, X., DeSantis, R., Kolaczynski, J., & Morris, M. (1993). Evidence that suppression of insulin secretion by insulin itself is neurally mediated. Metabolism, 42(6), 786-789. https://doi.org/10.1016/0026-0495(93)90250-R

Evidence that suppression of insulin secretion by insulin itself is neurally mediated. / Boden, Guenther; Chen, Xinhua; DeSantis, Richard; Kolaczynski, Jerzy; Morris, Michael.

In: Metabolism, Vol. 42, No. 6, 06.1993, p. 786-789.

Research output: Contribution to journalArticle

Boden, G, Chen, X, DeSantis, R, Kolaczynski, J & Morris, M 1993, 'Evidence that suppression of insulin secretion by insulin itself is neurally mediated', Metabolism, vol. 42, no. 6, pp. 786-789. https://doi.org/10.1016/0026-0495(93)90250-R
Boden, Guenther ; Chen, Xinhua ; DeSantis, Richard ; Kolaczynski, Jerzy ; Morris, Michael. / Evidence that suppression of insulin secretion by insulin itself is neurally mediated. In: Metabolism. 1993 ; Vol. 42, No. 6. pp. 786-789.
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