Evidence for Reduced Cerebellar Volumes in Trichotillomania

Nancy J. Keuthen, Nikos Makris, John E. Schlerf, Brian Martis, Cary R. Savage, Katherine McMullin, Larry J. Seidman, Jeremy D. Schmahmann, David N. Kennedy, Steven M. Hodge, Scott L. Rauch

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Background: Limited knowledge exists regarding the neurobiology of trichotillomania (TTM). Cerebellum (CBM) volumes were explored, given its role in complex, coordinated motor sequences. Methods: Morphometric magnetic resonance imaging (MRI) scans were obtained for 14 female subjects with DSM-IV diagnoses of TTM and 12 age-, education-, and gender-matched normal control (NC) participants. Parcellation was performed utilizing a recently developed methodology to measure subterritory volumes of the CBM. Regions were defined based on knowledge of the structural and functional subunits of the CBM. Results: As predicted, significant group differences were reported for CBM raw cortical volumes (p = .008) that survived correction for total brain volume (TBV; p = .037) and head circumference (HC; p = .011). A priori and post hoc group raw volume comparisons for CBM subterritories and functional clusters revealed many significant differences. However, most differences failed to withstand correction for total CBM volumes (TCV). Smaller volumes were consistently reported for the TTM versus NC cohorts. Total Massachusetts General Hospital Hair Pulling Scale (MGHHPS) scores were significantly inversely correlated with left primary sensorimotor cluster volumes (p = .008), with smaller volumes associated with more severe TTM symptoms. Conclusions: These findings implicate the CBM in the neurobiology of TTM, with reduced subterritory volumes reported for the TTM versus NC groups.

Original languageEnglish (US)
Pages (from-to)374-381
Number of pages8
JournalBiological Psychiatry
Volume61
Issue number3
DOIs
StatePublished - Feb 1 2007

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Trichotillomania
Cerebellum
Neurobiology
General Hospitals
Diagnostic and Statistical Manual of Mental Disorders
Head
Magnetic Resonance Imaging
Education
Control Groups
Brain

Keywords

  • Cerebellum
  • MRI
  • OC spectrum
  • hair pulling
  • morphometry
  • trichotillomania

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Keuthen, N. J., Makris, N., Schlerf, J. E., Martis, B., Savage, C. R., McMullin, K., ... Rauch, S. L. (2007). Evidence for Reduced Cerebellar Volumes in Trichotillomania. Biological Psychiatry, 61(3), 374-381. https://doi.org/10.1016/j.biopsych.2006.06.013

Evidence for Reduced Cerebellar Volumes in Trichotillomania. / Keuthen, Nancy J.; Makris, Nikos; Schlerf, John E.; Martis, Brian; Savage, Cary R.; McMullin, Katherine; Seidman, Larry J.; Schmahmann, Jeremy D.; Kennedy, David N.; Hodge, Steven M.; Rauch, Scott L.

In: Biological Psychiatry, Vol. 61, No. 3, 01.02.2007, p. 374-381.

Research output: Contribution to journalArticle

Keuthen, NJ, Makris, N, Schlerf, JE, Martis, B, Savage, CR, McMullin, K, Seidman, LJ, Schmahmann, JD, Kennedy, DN, Hodge, SM & Rauch, SL 2007, 'Evidence for Reduced Cerebellar Volumes in Trichotillomania', Biological Psychiatry, vol. 61, no. 3, pp. 374-381. https://doi.org/10.1016/j.biopsych.2006.06.013
Keuthen NJ, Makris N, Schlerf JE, Martis B, Savage CR, McMullin K et al. Evidence for Reduced Cerebellar Volumes in Trichotillomania. Biological Psychiatry. 2007 Feb 1;61(3):374-381. https://doi.org/10.1016/j.biopsych.2006.06.013
Keuthen, Nancy J. ; Makris, Nikos ; Schlerf, John E. ; Martis, Brian ; Savage, Cary R. ; McMullin, Katherine ; Seidman, Larry J. ; Schmahmann, Jeremy D. ; Kennedy, David N. ; Hodge, Steven M. ; Rauch, Scott L. / Evidence for Reduced Cerebellar Volumes in Trichotillomania. In: Biological Psychiatry. 2007 ; Vol. 61, No. 3. pp. 374-381.
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