Evidence for clonal evolution in pre‐B‐cell leukaemia

Minnie Abromowitch, Dorothy L. Williams, Susan L. Melvin, Sanford Stass

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Abstract

Summary. This case study provides evidence for clonal evolution in pre‐B‐cell leukaemia. At diagnosis, the lymphoblasts from a 3‐year‐old boy were morphologically subtyped as L1 (French–American–British classification). Their immunophenotype was CALLA+, CIgM+, SIg, TdT+, and the karyotype was pseudodiploid with a 1;19 translocation. Striking shifts were apparent when the child relapsed 16 months later. The morphologic subtype had changed to L3, CALLA and TdT had disappeared, and a consistent karyotype was lacking. The modal chromosome number had increased through clonal evolution to 85, the 1;19 translocation was retained, and a new marker, a 14q+ (partial duplication) appeared and was present in a majority of cells. These cytogenetic findings are characteristic of a transforming state. However, despite the loss of TdT, the appearance of classic L3 morphology and the acquisition of a 14q+ marker, the cells retained a predominantly pre‐B phenotype.

Original languageEnglish (US)
Pages (from-to)409-416
Number of pages8
JournalBritish Journal of Haematology
Volume56
Issue number3
DOIs
Publication statusPublished - Mar 1984

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ASJC Scopus subject areas

  • Hematology

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