Evidence for a novel gene associated with low tumor metastatic potential

Patricia S. Steeg, Generoso Bevilacqua, Laszlo Kopper, Unnur P. Thorgeirsson, James E. Talmadge, Lance A. Liotta, Mark E. Sobel

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Abstract

We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200-204]

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalJournal of the National Cancer Institute
Volume80
Issue number3
DOIs
StatePublished - Apr 6 1988

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Steeg, P. S., Bevilacqua, G., Kopper, L., Thorgeirsson, U. P., Talmadge, J. E., Liotta, L. A., & Sobel, M. E. (1988). Evidence for a novel gene associated with low tumor metastatic potential. Journal of the National Cancer Institute, 80(3), 200-204. https://doi.org/10.1093/jnci/80.3.200