Evidence for a novel gene associated with low tumor metastatic potential

Patricia S. Steeg, Generoso Bevilacqua, Laszlo Kopper, Unnur P. Thorgeirsson, James E. Talmadge, Lance A. Liotta, Mark E. Sobel

Research output: Contribution to journalArticle

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Abstract

We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200-204]

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalJournal of the National Cancer Institute
Volume80
Issue number3
DOIs
StatePublished - Apr 6 1988

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RNA
Tumors
Tumor
Genes
Gene
Cell
Rats
Neoplasms
Melanoma
Animals
Cells
CDNA
Proteins
Clone
Correlate
Cancer
Breast
Complementary DNA
Clone Cells
Protein

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Steeg, P. S., Bevilacqua, G., Kopper, L., Thorgeirsson, U. P., Talmadge, J. E., Liotta, L. A., & Sobel, M. E. (1988). Evidence for a novel gene associated with low tumor metastatic potential. Journal of the National Cancer Institute, 80(3), 200-204. https://doi.org/10.1093/jnci/80.3.200

Evidence for a novel gene associated with low tumor metastatic potential. / Steeg, Patricia S.; Bevilacqua, Generoso; Kopper, Laszlo; Thorgeirsson, Unnur P.; Talmadge, James E.; Liotta, Lance A.; Sobel, Mark E.

In: Journal of the National Cancer Institute, Vol. 80, No. 3, 06.04.1988, p. 200-204.

Research output: Contribution to journalArticle

Steeg, PS, Bevilacqua, G, Kopper, L, Thorgeirsson, UP, Talmadge, JE, Liotta, LA & Sobel, ME 1988, 'Evidence for a novel gene associated with low tumor metastatic potential', Journal of the National Cancer Institute, vol. 80, no. 3, pp. 200-204. https://doi.org/10.1093/jnci/80.3.200
Steeg, Patricia S. ; Bevilacqua, Generoso ; Kopper, Laszlo ; Thorgeirsson, Unnur P. ; Talmadge, James E. ; Liotta, Lance A. ; Sobel, Mark E. / Evidence for a novel gene associated with low tumor metastatic potential. In: Journal of the National Cancer Institute. 1988 ; Vol. 80, No. 3. pp. 200-204.
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