Event-related potentials in cocaine-exposed children during a Stroop task

Linda C. Mayes, Dennis L. Molfese, Alexandra P.F. Key, Nicole C. Hunter

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Objective: Prenatal cocaine-exposure may interfere with the ontogeny of prefrontal cortical executive functions due to cocaine's effect on the developing monoaminergic system. This study presents findings regarding cortical functioning in 29 prenatally cocaine-exposed (CE) and non-drug-exposed (NDE) 7- to 9-year-old children participating in event related potential (ERP) studies. Methods: ERPs were recorded using 128-electrode high-density arrays while children responded to a standard Stroop paradigm. Results: In the Stroop paradigm, CE children generated prolonged responses to the words while the NDE children produced briefer responses. Effects were noted in the region of the initial positive peak (P1), the second negative peak (N2) and the later positive peak (P3). Conclusions: Early cocaine exposure may inhibit the specialization and streamlining of brain region involvement during cognitive processing such that task processing is slower to begin, requires more diverse cortical involvement, and requires more time to complete. ERP methodology has considerable potential for studying frontal maturation and may provide additional information to clarify generally the specific effects of prenatal CE on cortical functioning and the developmental course of cognitive functions.

Original languageEnglish (US)
Pages (from-to)797-813
Number of pages17
JournalNeurotoxicology and Teratology
Volume27
Issue number6
DOIs
StatePublished - Nov 1 2005

Fingerprint

Cocaine
Evoked Potentials
Stroop Test
Enterprise resource planning
Executive Function
Processing
Cognition
Brain
Electrodes

Keywords

  • Cortical maturation
  • Event-related potential
  • Prenatal cocaine exposure

ASJC Scopus subject areas

  • Toxicology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Event-related potentials in cocaine-exposed children during a Stroop task. / Mayes, Linda C.; Molfese, Dennis L.; Key, Alexandra P.F.; Hunter, Nicole C.

In: Neurotoxicology and Teratology, Vol. 27, No. 6, 01.11.2005, p. 797-813.

Research output: Contribution to journalArticle

Mayes, Linda C. ; Molfese, Dennis L. ; Key, Alexandra P.F. ; Hunter, Nicole C. / Event-related potentials in cocaine-exposed children during a Stroop task. In: Neurotoxicology and Teratology. 2005 ; Vol. 27, No. 6. pp. 797-813.
@article{18be5b2eb40644158369b3a760560232,
title = "Event-related potentials in cocaine-exposed children during a Stroop task",
abstract = "Objective: Prenatal cocaine-exposure may interfere with the ontogeny of prefrontal cortical executive functions due to cocaine's effect on the developing monoaminergic system. This study presents findings regarding cortical functioning in 29 prenatally cocaine-exposed (CE) and non-drug-exposed (NDE) 7- to 9-year-old children participating in event related potential (ERP) studies. Methods: ERPs were recorded using 128-electrode high-density arrays while children responded to a standard Stroop paradigm. Results: In the Stroop paradigm, CE children generated prolonged responses to the words while the NDE children produced briefer responses. Effects were noted in the region of the initial positive peak (P1), the second negative peak (N2) and the later positive peak (P3). Conclusions: Early cocaine exposure may inhibit the specialization and streamlining of brain region involvement during cognitive processing such that task processing is slower to begin, requires more diverse cortical involvement, and requires more time to complete. ERP methodology has considerable potential for studying frontal maturation and may provide additional information to clarify generally the specific effects of prenatal CE on cortical functioning and the developmental course of cognitive functions.",
keywords = "Cortical maturation, Event-related potential, Prenatal cocaine exposure",
author = "Mayes, {Linda C.} and Molfese, {Dennis L.} and Key, {Alexandra P.F.} and Hunter, {Nicole C.}",
year = "2005",
month = "11",
day = "1",
doi = "10.1016/j.ntt.2005.05.011",
language = "English (US)",
volume = "27",
pages = "797--813",
journal = "Neurotoxicology and Teratology",
issn = "0892-0362",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Event-related potentials in cocaine-exposed children during a Stroop task

AU - Mayes, Linda C.

AU - Molfese, Dennis L.

AU - Key, Alexandra P.F.

AU - Hunter, Nicole C.

PY - 2005/11/1

Y1 - 2005/11/1

N2 - Objective: Prenatal cocaine-exposure may interfere with the ontogeny of prefrontal cortical executive functions due to cocaine's effect on the developing monoaminergic system. This study presents findings regarding cortical functioning in 29 prenatally cocaine-exposed (CE) and non-drug-exposed (NDE) 7- to 9-year-old children participating in event related potential (ERP) studies. Methods: ERPs were recorded using 128-electrode high-density arrays while children responded to a standard Stroop paradigm. Results: In the Stroop paradigm, CE children generated prolonged responses to the words while the NDE children produced briefer responses. Effects were noted in the region of the initial positive peak (P1), the second negative peak (N2) and the later positive peak (P3). Conclusions: Early cocaine exposure may inhibit the specialization and streamlining of brain region involvement during cognitive processing such that task processing is slower to begin, requires more diverse cortical involvement, and requires more time to complete. ERP methodology has considerable potential for studying frontal maturation and may provide additional information to clarify generally the specific effects of prenatal CE on cortical functioning and the developmental course of cognitive functions.

AB - Objective: Prenatal cocaine-exposure may interfere with the ontogeny of prefrontal cortical executive functions due to cocaine's effect on the developing monoaminergic system. This study presents findings regarding cortical functioning in 29 prenatally cocaine-exposed (CE) and non-drug-exposed (NDE) 7- to 9-year-old children participating in event related potential (ERP) studies. Methods: ERPs were recorded using 128-electrode high-density arrays while children responded to a standard Stroop paradigm. Results: In the Stroop paradigm, CE children generated prolonged responses to the words while the NDE children produced briefer responses. Effects were noted in the region of the initial positive peak (P1), the second negative peak (N2) and the later positive peak (P3). Conclusions: Early cocaine exposure may inhibit the specialization and streamlining of brain region involvement during cognitive processing such that task processing is slower to begin, requires more diverse cortical involvement, and requires more time to complete. ERP methodology has considerable potential for studying frontal maturation and may provide additional information to clarify generally the specific effects of prenatal CE on cortical functioning and the developmental course of cognitive functions.

KW - Cortical maturation

KW - Event-related potential

KW - Prenatal cocaine exposure

UR - http://www.scopus.com/inward/record.url?scp=27844464065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27844464065&partnerID=8YFLogxK

U2 - 10.1016/j.ntt.2005.05.011

DO - 10.1016/j.ntt.2005.05.011

M3 - Article

C2 - 16111858

AN - SCOPUS:27844464065

VL - 27

SP - 797

EP - 813

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - 6

ER -