Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes

Dominic E Cosgrove, Helen Bodmer, Molly Bogue, Christophe Benoist, Diane Mathis

Research output: Contribution to journalArticle

27 Scopus citations


Most mice display two conventional major histocompatibility complex class II isotypes, A and E. Several A+E strains have been observed, but never any that are A-E+. Because of this and because of hints from several lines of functional analysis, it has been proposed that the two isotypes might not operate equivalently. This proposition has not been directly testable until now because of the lack of an E-only strain. We report the production of such mice, exploiting previously created class II-transgenic and dass II-“knock-out” lines. A+E, AE, and AE+ littermates have been compared by a number of parameters. We find that E and A molecules are, for the most part, functionally equivalent. However, subtle differences are seen in their ability to engage CD4 molecules on immature thymocytes, and in the profile of receptors on T cells selected into the periphery.

Original languageEnglish (US)
Pages (from-to)629-634
Number of pages6
JournalJournal of Experimental Medicine
Issue number2
Publication statusPublished - Aug 1 1992


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this