Evaluation of the dosimetric feasibility of hippocampal sparing intensity-modulated radiotherapy in patients with locally advanced nasopharyngeal carcinoma

Guang Han, Dong Liu, Hua Gan, Kyle A. Denniston, Sicong Li, Wenyong Tan, Desheng Hu, Weining Zhen, Zhaohua Wang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: The objective of this study was to evaluate the dosimetric feasibility of using hippocampus (HPC) sparing intensity-modulated radiotherapy (IMRT) in patients with locally advanced nasopharyngeal carcinoma (NPC). Materials/Methods: Eight cases of either T3 or T4 NPC were selected for this study. Standard IMRT treatment plans were constructed using the volume and dose constraints for the targets and organs at risk (OAR) per Radiation Therapy Oncology Group (RTOG) 0615 protocol. Experimental plans were constructed using the same criteria, with the addition of the HPC as an OAR. The two dose-volume histograms for each case were compared for the targets and OARs. Results: All plans achieved the protocol dose criteria. The homogeneity index, conformity index, and coverage index for the planning target volumes (PTVs) were not significantly compromised by the avoidance of the HPC. The doses to all OARs, excluding the HPC, were similar. Both the dose (Dmax, D2%, D40%, Dmean, Dmedian, D98% and Dmin) and volume (V5, V10, V15, 20, V30, V40 and V50) parameters for the HPC were significantly lower in the HPC sparing plans (P<0.05), except for Dmin (P = 0.06) and V5 (P = 0.12). Conclusions: IMRT for patients with locally advanced NPC exposes the HPC to a significant radiation dose. HPC sparing IMRT planning significantly decreases this dose, with minimal impact on the therapeutic targets and other OARs.

Original languageEnglish (US)
Article numbere90007
JournalPloS one
Volume9
Issue number2
DOIs
StatePublished - Feb 28 2014

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Intensity-Modulated Radiotherapy
Radiotherapy
radiotherapy
hippocampus
carcinoma
Hippocampus
dosage
Dosimetry
Organs at Risk
Planning
Oncology
planning
Radiation Oncology
Nasopharyngeal carcinoma
Radiation
therapeutics
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Evaluation of the dosimetric feasibility of hippocampal sparing intensity-modulated radiotherapy in patients with locally advanced nasopharyngeal carcinoma. / Han, Guang; Liu, Dong; Gan, Hua; Denniston, Kyle A.; Li, Sicong; Tan, Wenyong; Hu, Desheng; Zhen, Weining; Wang, Zhaohua.

In: PloS one, Vol. 9, No. 2, e90007, 28.02.2014.

Research output: Contribution to journalArticle

Han, Guang ; Liu, Dong ; Gan, Hua ; Denniston, Kyle A. ; Li, Sicong ; Tan, Wenyong ; Hu, Desheng ; Zhen, Weining ; Wang, Zhaohua. / Evaluation of the dosimetric feasibility of hippocampal sparing intensity-modulated radiotherapy in patients with locally advanced nasopharyngeal carcinoma. In: PloS one. 2014 ; Vol. 9, No. 2.
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AB - Purpose: The objective of this study was to evaluate the dosimetric feasibility of using hippocampus (HPC) sparing intensity-modulated radiotherapy (IMRT) in patients with locally advanced nasopharyngeal carcinoma (NPC). Materials/Methods: Eight cases of either T3 or T4 NPC were selected for this study. Standard IMRT treatment plans were constructed using the volume and dose constraints for the targets and organs at risk (OAR) per Radiation Therapy Oncology Group (RTOG) 0615 protocol. Experimental plans were constructed using the same criteria, with the addition of the HPC as an OAR. The two dose-volume histograms for each case were compared for the targets and OARs. Results: All plans achieved the protocol dose criteria. The homogeneity index, conformity index, and coverage index for the planning target volumes (PTVs) were not significantly compromised by the avoidance of the HPC. The doses to all OARs, excluding the HPC, were similar. Both the dose (Dmax, D2%, D40%, Dmean, Dmedian, D98% and Dmin) and volume (V5, V10, V15, 20, V30, V40 and V50) parameters for the HPC were significantly lower in the HPC sparing plans (P<0.05), except for Dmin (P = 0.06) and V5 (P = 0.12). Conclusions: IMRT for patients with locally advanced NPC exposes the HPC to a significant radiation dose. HPC sparing IMRT planning significantly decreases this dose, with minimal impact on the therapeutic targets and other OARs.

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