Evaluation of technique for autotransplantation of the spleen in dogs

J. M. Sterchi, D. L. Evans, M. A. Hollingsworth, J. J. Brown, T. P. Mutton, M. Chung

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Preservation of the human spleen is important in the prevention of overwhelming sepsis, particularly in infants and immunosuppressed patients. When that preservation is not possible, due to disease or severe trauma, it has been suggested that autotransplantation of splenic tissue might provide adequate immunological protection. This study looked at the feasibility of autotransplantation via subcutaneous implantation in the dog. This method is important, since controlled intraabdominal splenosis is very difficult to achieve. The adverse effect of splenectomy, as well as the ineffectiveness of autotransplantation was demonstrated in providing demonstrable in vitro evidence of decreased sheep red blood cell immunization, even though the subcutaneous implantation itself was successful. From this study, the authors suspected, but could not prove, that the ineffectiveness of the splenic autotransplants was related to their lack of critical mass for good bacterial clearance from the blood stream and the fact that they did not lie within the main vascular channels, probably a criterion for proper clearance. The role of splenic preservation by autotransplantation needs to be evaluated in the immature host.

Original languageEnglish (US)
Pages (from-to)625-631
Number of pages7
JournalAmerican Surgeon
Volume49
Issue number11
StatePublished - Dec 1 1983

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Autologous Transplantation
Spleen
Dogs
Splenosis
Autografts
Splenectomy
Blood Vessels
Immunization
Sheep
Sepsis
Erythrocytes
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

Cite this

Sterchi, J. M., Evans, D. L., Hollingsworth, M. A., Brown, J. J., Mutton, T. P., & Chung, M. (1983). Evaluation of technique for autotransplantation of the spleen in dogs. American Surgeon, 49(11), 625-631.

Evaluation of technique for autotransplantation of the spleen in dogs. / Sterchi, J. M.; Evans, D. L.; Hollingsworth, M. A.; Brown, J. J.; Mutton, T. P.; Chung, M.

In: American Surgeon, Vol. 49, No. 11, 01.12.1983, p. 625-631.

Research output: Contribution to journalArticle

Sterchi, JM, Evans, DL, Hollingsworth, MA, Brown, JJ, Mutton, TP & Chung, M 1983, 'Evaluation of technique for autotransplantation of the spleen in dogs', American Surgeon, vol. 49, no. 11, pp. 625-631.
Sterchi JM, Evans DL, Hollingsworth MA, Brown JJ, Mutton TP, Chung M. Evaluation of technique for autotransplantation of the spleen in dogs. American Surgeon. 1983 Dec 1;49(11):625-631.
Sterchi, J. M. ; Evans, D. L. ; Hollingsworth, M. A. ; Brown, J. J. ; Mutton, T. P. ; Chung, M. / Evaluation of technique for autotransplantation of the spleen in dogs. In: American Surgeon. 1983 ; Vol. 49, No. 11. pp. 625-631.
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