Evaluation of superficial bladder transitional-cell carcinoma by optical coherence tomography

Michael J. Manyak, Natalia D. Gladkova, John H. Makari, Arnold M. Schwartz, Elena V. Zagaynova, Ladan Zolfaghari, Jason M. Zara, Rashid Iksanov, Felix I. Feldchtein

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Background and Purpose: Optical coherence tomography (OCT) is a new modality that allows noninvasive examination of the internal structure of biological tissue in vivo with a spatial resolution of 10 to 15 μm. This study evaluated the clinical application of OCT to determine epithelial and subepithelial anatomic structure and invasiveness of bladder epithelial lesions. Materials and Methods: The OCT examination was performed with a 980-nm 10 mW superluminescent diode using a 2.7-mm-diameter optical fiber positioned cystoscopically. A total of 261 scans of 1.5 seconds' duration, which generated 200 × 200-pixel images, were performed on 87 areas in 24 patients at high risk of having transitional-cell carcinoma (TCC). Lesions, visually suspect, and normal areas were photographed, scanned, and biopsied. The scans were evaluated independently before comparison with histopathology findings. Results: Of the 87 areas, 29 of 36 visually suspect areas and 35 of 35 normal areas, were correctly diagnosed with OCT. Of the 16 areas with papillary TCC, all 16 were diagnosed correctly as tumor, and 9 of 10 were diagnosed correctly as invasive, including 6 with lamina propria invasion only. Papillary and flat tumors, carcinoma in situ, inflammation, chronic cystitis, and von Brunn's nests were scanned. Overall, OCT had a sensitivity of 100%, overall specificity of 89%, positive predictive value of 75%, and negative predictive value of 100%. The accuracy was 92%. The positive predictive value for invasion was 90%. Conclusion: Optical coherence tomography is a simple, portable, promising modality for evaluation of bladder lesions and depth of tumor penetration. Further refinement of this technology may lead to the development of an optical surrogate for biopsy.

Original languageEnglish (US)
Pages (from-to)570-574
Number of pages5
JournalJournal of Endourology
Volume19
Issue number5
DOIs
StatePublished - Jun 1 2005

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Transitional Cell Carcinoma
Optical Coherence Tomography
Urinary Bladder
Optical Fibers
Neoplasms
Cystitis
Papillary Carcinoma
Carcinoma in Situ
Mucous Membrane
Inflammation
Technology
Biopsy

ASJC Scopus subject areas

  • Urology

Cite this

Manyak, M. J., Gladkova, N. D., Makari, J. H., Schwartz, A. M., Zagaynova, E. V., Zolfaghari, L., ... Feldchtein, F. I. (2005). Evaluation of superficial bladder transitional-cell carcinoma by optical coherence tomography. Journal of Endourology, 19(5), 570-574. https://doi.org/10.1089/end.2005.19.570

Evaluation of superficial bladder transitional-cell carcinoma by optical coherence tomography. / Manyak, Michael J.; Gladkova, Natalia D.; Makari, John H.; Schwartz, Arnold M.; Zagaynova, Elena V.; Zolfaghari, Ladan; Zara, Jason M.; Iksanov, Rashid; Feldchtein, Felix I.

In: Journal of Endourology, Vol. 19, No. 5, 01.06.2005, p. 570-574.

Research output: Contribution to journalArticle

Manyak, MJ, Gladkova, ND, Makari, JH, Schwartz, AM, Zagaynova, EV, Zolfaghari, L, Zara, JM, Iksanov, R & Feldchtein, FI 2005, 'Evaluation of superficial bladder transitional-cell carcinoma by optical coherence tomography', Journal of Endourology, vol. 19, no. 5, pp. 570-574. https://doi.org/10.1089/end.2005.19.570
Manyak, Michael J. ; Gladkova, Natalia D. ; Makari, John H. ; Schwartz, Arnold M. ; Zagaynova, Elena V. ; Zolfaghari, Ladan ; Zara, Jason M. ; Iksanov, Rashid ; Feldchtein, Felix I. / Evaluation of superficial bladder transitional-cell carcinoma by optical coherence tomography. In: Journal of Endourology. 2005 ; Vol. 19, No. 5. pp. 570-574.
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AU - Zagaynova, Elena V.

AU - Zolfaghari, Ladan

AU - Zara, Jason M.

AU - Iksanov, Rashid

AU - Feldchtein, Felix I.

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N2 - Background and Purpose: Optical coherence tomography (OCT) is a new modality that allows noninvasive examination of the internal structure of biological tissue in vivo with a spatial resolution of 10 to 15 μm. This study evaluated the clinical application of OCT to determine epithelial and subepithelial anatomic structure and invasiveness of bladder epithelial lesions. Materials and Methods: The OCT examination was performed with a 980-nm 10 mW superluminescent diode using a 2.7-mm-diameter optical fiber positioned cystoscopically. A total of 261 scans of 1.5 seconds' duration, which generated 200 × 200-pixel images, were performed on 87 areas in 24 patients at high risk of having transitional-cell carcinoma (TCC). Lesions, visually suspect, and normal areas were photographed, scanned, and biopsied. The scans were evaluated independently before comparison with histopathology findings. Results: Of the 87 areas, 29 of 36 visually suspect areas and 35 of 35 normal areas, were correctly diagnosed with OCT. Of the 16 areas with papillary TCC, all 16 were diagnosed correctly as tumor, and 9 of 10 were diagnosed correctly as invasive, including 6 with lamina propria invasion only. Papillary and flat tumors, carcinoma in situ, inflammation, chronic cystitis, and von Brunn's nests were scanned. Overall, OCT had a sensitivity of 100%, overall specificity of 89%, positive predictive value of 75%, and negative predictive value of 100%. The accuracy was 92%. The positive predictive value for invasion was 90%. Conclusion: Optical coherence tomography is a simple, portable, promising modality for evaluation of bladder lesions and depth of tumor penetration. Further refinement of this technology may lead to the development of an optical surrogate for biopsy.

AB - Background and Purpose: Optical coherence tomography (OCT) is a new modality that allows noninvasive examination of the internal structure of biological tissue in vivo with a spatial resolution of 10 to 15 μm. This study evaluated the clinical application of OCT to determine epithelial and subepithelial anatomic structure and invasiveness of bladder epithelial lesions. Materials and Methods: The OCT examination was performed with a 980-nm 10 mW superluminescent diode using a 2.7-mm-diameter optical fiber positioned cystoscopically. A total of 261 scans of 1.5 seconds' duration, which generated 200 × 200-pixel images, were performed on 87 areas in 24 patients at high risk of having transitional-cell carcinoma (TCC). Lesions, visually suspect, and normal areas were photographed, scanned, and biopsied. The scans were evaluated independently before comparison with histopathology findings. Results: Of the 87 areas, 29 of 36 visually suspect areas and 35 of 35 normal areas, were correctly diagnosed with OCT. Of the 16 areas with papillary TCC, all 16 were diagnosed correctly as tumor, and 9 of 10 were diagnosed correctly as invasive, including 6 with lamina propria invasion only. Papillary and flat tumors, carcinoma in situ, inflammation, chronic cystitis, and von Brunn's nests were scanned. Overall, OCT had a sensitivity of 100%, overall specificity of 89%, positive predictive value of 75%, and negative predictive value of 100%. The accuracy was 92%. The positive predictive value for invasion was 90%. Conclusion: Optical coherence tomography is a simple, portable, promising modality for evaluation of bladder lesions and depth of tumor penetration. Further refinement of this technology may lead to the development of an optical surrogate for biopsy.

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