Evaluation of outcomes of intravenous to oral antimicrobial conversion initiatives: A literature review

Rory Sallach-Ruma, Charleen Phan, Jayashri Sankaranarayanan

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Inappropriate use of antimicrobial agents could result in antimicrobial resistance that could impact clinical cure outcomes (by increasing morbidity in terms of increased adverse events and risk of secondary and hospital-acquired infections and mortality) and increase costs to health care institutions. Thus, appropriate antimicrobial use has become vital for balancing patient safety and costs and is therefore a focus for health care institutions. This is often achieved through efforts of antimicrobial stewardship programs that include intravenous to oral conversion initiatives with clinical pharmacists playing an instrumental role in their development and implementation with medical staff approval. However, the delivery and effectiveness of these programs are quite variable. Therefore, for guiding the successful delivery and evaluations of these programs in the future, the objective of this literature review is to document the impact of intravenous to oral conversion programs in terms of clinical and economic outcomes at various institutions worldwide along with the pharmacist's role in these programs.

Original languageEnglish (US)
Pages (from-to)703-729
Number of pages27
JournalExpert Review of Clinical Pharmacology
Volume6
Issue number6
DOIs
StatePublished - Nov 14 2013

Fingerprint

Program Evaluation
Pharmacists
Medical Staff
Patient Safety
Cross Infection
Hospital Mortality
Anti-Infective Agents
Health Care Costs
Economics
Morbidity
Delivery of Health Care
Costs and Cost Analysis

Keywords

  • antimicrobial stewardship
  • intravenous to oral antimicrobial conversion
  • pharmacists
  • review
  • sequential therapy conversion
  • step-down therapy conversion
  • switch therapy conversion

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Evaluation of outcomes of intravenous to oral antimicrobial conversion initiatives : A literature review. / Sallach-Ruma, Rory; Phan, Charleen; Sankaranarayanan, Jayashri.

In: Expert Review of Clinical Pharmacology, Vol. 6, No. 6, 14.11.2013, p. 703-729.

Research output: Contribution to journalReview article

Sallach-Ruma, Rory ; Phan, Charleen ; Sankaranarayanan, Jayashri. / Evaluation of outcomes of intravenous to oral antimicrobial conversion initiatives : A literature review. In: Expert Review of Clinical Pharmacology. 2013 ; Vol. 6, No. 6. pp. 703-729.
@article{2e140ee09d254dd7840e0840c3da2ea5,
title = "Evaluation of outcomes of intravenous to oral antimicrobial conversion initiatives: A literature review",
abstract = "Inappropriate use of antimicrobial agents could result in antimicrobial resistance that could impact clinical cure outcomes (by increasing morbidity in terms of increased adverse events and risk of secondary and hospital-acquired infections and mortality) and increase costs to health care institutions. Thus, appropriate antimicrobial use has become vital for balancing patient safety and costs and is therefore a focus for health care institutions. This is often achieved through efforts of antimicrobial stewardship programs that include intravenous to oral conversion initiatives with clinical pharmacists playing an instrumental role in their development and implementation with medical staff approval. However, the delivery and effectiveness of these programs are quite variable. Therefore, for guiding the successful delivery and evaluations of these programs in the future, the objective of this literature review is to document the impact of intravenous to oral conversion programs in terms of clinical and economic outcomes at various institutions worldwide along with the pharmacist's role in these programs.",
keywords = "antimicrobial stewardship, intravenous to oral antimicrobial conversion, pharmacists, review, sequential therapy conversion, step-down therapy conversion, switch therapy conversion",
author = "Rory Sallach-Ruma and Charleen Phan and Jayashri Sankaranarayanan",
year = "2013",
month = "11",
day = "14",
doi = "10.1586/17512433.2013.844647",
language = "English (US)",
volume = "6",
pages = "703--729",
journal = "Expert Review of Clinical Pharmacology",
issn = "1751-2433",
publisher = "Expert Reviews Ltd.",
number = "6",

}

TY - JOUR

T1 - Evaluation of outcomes of intravenous to oral antimicrobial conversion initiatives

T2 - A literature review

AU - Sallach-Ruma, Rory

AU - Phan, Charleen

AU - Sankaranarayanan, Jayashri

PY - 2013/11/14

Y1 - 2013/11/14

N2 - Inappropriate use of antimicrobial agents could result in antimicrobial resistance that could impact clinical cure outcomes (by increasing morbidity in terms of increased adverse events and risk of secondary and hospital-acquired infections and mortality) and increase costs to health care institutions. Thus, appropriate antimicrobial use has become vital for balancing patient safety and costs and is therefore a focus for health care institutions. This is often achieved through efforts of antimicrobial stewardship programs that include intravenous to oral conversion initiatives with clinical pharmacists playing an instrumental role in their development and implementation with medical staff approval. However, the delivery and effectiveness of these programs are quite variable. Therefore, for guiding the successful delivery and evaluations of these programs in the future, the objective of this literature review is to document the impact of intravenous to oral conversion programs in terms of clinical and economic outcomes at various institutions worldwide along with the pharmacist's role in these programs.

AB - Inappropriate use of antimicrobial agents could result in antimicrobial resistance that could impact clinical cure outcomes (by increasing morbidity in terms of increased adverse events and risk of secondary and hospital-acquired infections and mortality) and increase costs to health care institutions. Thus, appropriate antimicrobial use has become vital for balancing patient safety and costs and is therefore a focus for health care institutions. This is often achieved through efforts of antimicrobial stewardship programs that include intravenous to oral conversion initiatives with clinical pharmacists playing an instrumental role in their development and implementation with medical staff approval. However, the delivery and effectiveness of these programs are quite variable. Therefore, for guiding the successful delivery and evaluations of these programs in the future, the objective of this literature review is to document the impact of intravenous to oral conversion programs in terms of clinical and economic outcomes at various institutions worldwide along with the pharmacist's role in these programs.

KW - antimicrobial stewardship

KW - intravenous to oral antimicrobial conversion

KW - pharmacists

KW - review

KW - sequential therapy conversion

KW - step-down therapy conversion

KW - switch therapy conversion

UR - http://www.scopus.com/inward/record.url?scp=84887286863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887286863&partnerID=8YFLogxK

U2 - 10.1586/17512433.2013.844647

DO - 10.1586/17512433.2013.844647

M3 - Review article

C2 - 24164616

AN - SCOPUS:84887286863

VL - 6

SP - 703

EP - 729

JO - Expert Review of Clinical Pharmacology

JF - Expert Review of Clinical Pharmacology

SN - 1751-2433

IS - 6

ER -