Evaluation of growth hormone secretion in children with juvenile rheumatoid arthritis and short stature.

R. J. Hopp, J. Degan, Kevin Patrick Corley, C. B. Lindsley, J. T. Cassidy

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Abstract

Children with juvenile rheumatoid arthritis (JRA) often exhibit delayed skeletal development. Previous evaluations of growth hormone (hGH) levels in these children have used single-value blood determinations. We sought to extend information on possible hGH deficiency in children with short stature and JRA by measuring 24-hour hGH pulsatile secretion. Five children with JRA were identified as having a height less than the 3rd percentile, and one child with a height at the 25th percentile. Three of these had abnormally low 24-hour serum hGH secretion. Two underwent a 24-month trial of human recombinant hGH; both exhibited only marginally accelerated growth. These results suggest that children with JRA and persistent short stature may have low hGH secretion without an adequate physiologic response to exogenous hGH administration.

Original languageEnglish (US)
Pages (from-to)52-57
Number of pages6
JournalThe Nebraska medical journal
Volume80
Issue number3
StatePublished - Jan 1 1995

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Juvenile Arthritis
Growth Hormone
Growth
Serum

ASJC Scopus subject areas

  • Medicine(all)

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Hopp, R. J., Degan, J., Corley, K. P., Lindsley, C. B., & Cassidy, J. T. (1995). Evaluation of growth hormone secretion in children with juvenile rheumatoid arthritis and short stature. The Nebraska medical journal, 80(3), 52-57.

Evaluation of growth hormone secretion in children with juvenile rheumatoid arthritis and short stature. / Hopp, R. J.; Degan, J.; Corley, Kevin Patrick; Lindsley, C. B.; Cassidy, J. T.

In: The Nebraska medical journal, Vol. 80, No. 3, 01.01.1995, p. 52-57.

Research output: Contribution to journalArticle

Hopp, RJ, Degan, J, Corley, KP, Lindsley, CB & Cassidy, JT 1995, 'Evaluation of growth hormone secretion in children with juvenile rheumatoid arthritis and short stature.', The Nebraska medical journal, vol. 80, no. 3, pp. 52-57.
Hopp, R. J. ; Degan, J. ; Corley, Kevin Patrick ; Lindsley, C. B. ; Cassidy, J. T. / Evaluation of growth hormone secretion in children with juvenile rheumatoid arthritis and short stature. In: The Nebraska medical journal. 1995 ; Vol. 80, No. 3. pp. 52-57.
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